Publications by authors named "Xianzhou Feng"

Testosterone is a vital male hormone responsible for male sexual characteristics. The taste receptor family 1 subunit 3 (T1R3) regulates testosterone synthesis and autophagy in non-taste cells, and the links with the taste receptor family 1 subunit 1 (T1R1) for umami perception. However, little is known about these mechanisms.

View Article and Find Full Text PDF
Article Synopsis
  • T1R3 is a taste receptor in mammals that helps recognize sweet and umami flavors and is important for nutrient absorption and hormone regulation.
  • In this study, inhibiting T1R3 led to decreased expression of steroidogenic enzymes and significantly reduced levels of various hormones including testosterone in Leydig cells.
  • Conversely, activating T1R3 with substances like saccharin sodium increased hormone levels and cAMP accumulation, indicating that T1R3 is crucial for steroid hormone production in testes.
View Article and Find Full Text PDF

In mammals, sperm acquire fertilization ability after capacitation in vitro or when in the female reproductive tract. The motility patterns of sperm undergo continuous changes from the moment of ejaculation until fertilization in the female reproductive tract. In vitro, hyperactivated motility can be induced through high glucose mediums, while in vivo, it is induced by oviduct fluids.

View Article and Find Full Text PDF

The optimized fixative for testis is still controversial. This study investigated the effects of Modified Davidson's Fluid (mDF), 4% Paraformaldehyde (4% PFA), and Bouin's Fluid (BF) fixatives on chicken testes in normal/cadmium (Cd) feeding groups using hematoxylin and eosin (HE), immunohistochemistry (IHC), and Terminal Transferase dUTP Nick End Labeling (TUNEL) staining. Compared to the mDF, we established that the testes fixed with 4% PFA and BF in the normal group had severe shrinkage in tubular and interstitial compartments.

View Article and Find Full Text PDF