The impact of high-glucose or high-fat diets on the metabolomic profiling of mice.

Objective: Diets high in glucose or fat contribute to an increased prevalence of the diseases. Therefore, the objective of the current research was to observe and evaluate the impact of dietary components on different metabolomic profiles in primary tissues of mice.

Methods: For 8 weeks, diet with high-glucose or-fat was given to C57BL/6 J mice.

Glucagon-like peptide 1 receptor agonist therapy is more efficacious than insulin glargine for poorly controlled type 2 diabetes: A systematic review and meta-analysis.

Background: The aim of the present study was to compare the reported efficacy and safety of glucagon-like peptide-l receptor agonist (GLP-1RA) and insulin glargine (IGlar) for poorly controlled type 2 diabetes.

Methods: Medline, EMBASE, Cochrane Library, and clinicaltrials.gov were carried out.