Publications by authors named "Xianzhen Pan"
Background: The remodeling of maternal spiral artery following embryo implantation, which relies on well-regulated trophoblast functions, is a pivotal process to ensure a successful pregnancy. Low-density lipoprotein receptor-related protein 6 (LRP6) and microRNAs (miRNAs, miRs) are suggested to be involved in angiogenesis and several vascular diseases; however, their functions in the control of trophoblast remain elusive. We therefore aimed to examine the roles of LRP6 and miR-590-3p in the regulation of trophoblast during the remodeling of maternal spiral artery.
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- Preeclampsia is linked to issues with trophoblast invasion and is influenced by hypoxia, although the exact molecular mechanisms remain unclear.
- The study investigated heme oxygenase 1 (HO-1) and its role in preeclampsia by analyzing its expression and that of STAT3 in placental tissues and in JEG-3 cells under hypoxic conditions.
- Results showed that while HO-1 was upregulated in preeclamptic placentas, phosphorylated STAT3 levels were reduced, suggesting that HO-1 may inhibit STAT3 phosphorylation under hypoxia, potentially contributing to preeclampsia pathology.
Abnormal maternal trophoblast invasion is a common finding in preeclampsia pregnancy. A hypoxic environment develops in the placenta after the 10th week of pregnancy and exerts a major influence over trophoblast activity. In the present study, we investigated expression of miR-222 and apoptosis-related BCL2L11 in preeclampsia placenta and in primary placenta mesenchymal stem cells (MSCs) under hypoxia.
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