Publications by authors named "Xianzhen He"

Type 1 diabetes mellitus (T1DM), a complex chronic disease with an intricate etiology and pathogenesis, involves the recognition of self-antigens by pancreatic islet autoantigen-specific T cells and plays crucial roles in both early- and late-stage destruction of beta cells, thus impacting disease progression. Antigen-specific T cells regulate and execute immune responses by recognizing particular antigens, playing broad roles in the treatment of various diseases. Immunotherapy targeting antigen-specific T cells holds promising potential as a targeted treatment approach.

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Article Synopsis
  • GLP-1RA is a new medication for type 2 diabetes that helps lower blood sugar levels, reduce inflammation, promote weight loss, and lower blood fats.
  • The study explores how GLP-1RAs may influence cell growth and survival, as well as their potential impact on cancer prognosis.
  • The research aims to offer fresh perspectives on using GLP-1RAs for preventing and treating tumors in patients.
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Unlabelled: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination is crucial for protecting vulnerable individuals, yet individuals with type 2 diabetes mellitus (T2DM) often exhibit impaired vaccine responses. Emerging evidence suggests that the composition of the host microbiota, crucial in immune regulation and development, influences vaccine efficacy. This study aimed to characterize the relationships between the SARS-CoV-2 inactivated vaccine and the host microbiota (specifically, gut and lung microbiota) of C57BL/6 mice with T2DM.

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