Publications by authors named "Xianyue Jiang"
Article Synopsis
- The emergence of CRISPR-Cas systems has led to the development of efficient gene editing tools, but traditional methods for discovering these systems often overlook important variants due to their reliance on sequence similarity.* -
- A new AI framework called CHOOSER has been introduced to discover CRISPR-Cas systems without needing extensive training data, significantly enhancing the discovery process by utilizing protein large language models.* -
- Using CHOOSER, researchers identified 11 new Casλ homologs, doubling the known catalog, and experimentally validated one homolog, EphcCasλ, for its capability in self-processing pre-crRNA and potential in CRISPR-based pathogen detection.*
Bacteria have evolved diverse mechanisms to fend off predation by bacteriophages. We previously identified the Dnd system, which uses DndABCDE to insert sulfur into the DNA backbone as a double-stranded phosphorothioate (PT) modification, and DndFGH, a restriction component. Here, we describe an unusual SspABCD-SspE PT system in Vibrio cyclitrophicus, Escherichia coli and Streptomyces yokosukanensis, which has distinct genetic organization, biochemical functions and phenotypic behaviour.
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