Potential Regional Pollination Services of (Lepidoptera: Noctuidae) Migrants as Evidenced by the Identification of Attached Pollen.

Many species of noctuid moths exhibit long-distance migratory behavior and have an important pollination service function in terrestrial ecosystems. (Fabricius) is a globally distributed insect; however, its role in pollination remains underexplored. In this study, the feeding preferences and inter regional pollination of adults were explored.

Seasonal Migratory Activity of the Beet Armyworm (Hübner) in the Tropical Area of China.

The beet armyworm (Hübner), a global pest, feeds on and affects a wide range of crops. Its long-distance migration with the East Asian monsoon frequently causes large-scale outbreaks in East and Southeast Asia. This pest mainly breeds in tropical regions in the winter season every year; however, few studies have investigated associations with its population movements in this region.

VEGFD/VEGFR3 signaling contributes to the dysfunction of the astrocyte IL-3/microglia IL-3Rα cross-talk and drives neuroinflammation in mouse ischemic stroke.

Astrocyte-derived IL-3 activates the corresponding receptor IL-3Rα in microglia. This cross-talk between astrocytes and microglia ameliorates the pathology of Alzheimer's disease in mice. In this study we investigated the role of IL-3/IL-3Rα cross-talk and its regulatory mechanisms in ischemic stroke.

Matrilin-3 supports neuroprotection in ischemic stroke by suppressing astrocyte-mediated neuroinflammation.

In the brain, the role of matrilin-3, an extracellular matrix component in cartilage, is unknown. Here, we identify that matrilin-3 decreased in reactive astrocytes but was unchanged in neurons after ischemic stroke in animals. Importantly, it declined in serum of patients with acute ischemic stroke.

The brain protection of MLKL inhibitor necrosulfonamide against focal ischemia/reperfusion injury associating with blocking the nucleus and nuclear envelope translocation of MLKL and RIP3K.

Mixed lineage kinase like protein (MLKL) is a key mediator of necroptosis. While previous studies highlighted the important role of MLKL as one of the central regulators of brain damage against acute ischemic neuronal injury, how the activation of MLKL mediates brain injuries and cell death remains unclear, especially in astrocytes. In a transient middle cerebral artery occlusion (tMCAO) rat model , and an oxygen-glucose deprivation and reoxygenation (OGD/Re) injury model in both primary cultured astrocytes and human astrocytes, we show that necrosulfonamide (NSA), a MLKL specific inhibitor, reduces infarction volume and improves neurological deficits in tMCAO-treated rats.

Cross-Regional Pollination Behavior of between China and the Indo-China Peninsula.

Noctuid moths, a group of "non-bee" pollinators, are essential but frequently underappreciated. To elucidate their roles in cross-regional pollination, this study selected the agriculturally significant species, cabbage looper (CL) , as a representative model. From 2017 to 2021, this study was conducted on Yongxing Island, situated at the center of the South China Sea.

Quenching Detrimental Reactions and Boosting Hole Extraction via Multifunctional NiO /Perovskite Interface Passivation for Efficient and Stable Inverted Solar Cells.

Nickel oxide (NiO ) is one of the most promising hole transport materials for inverted perovskite solar cells (PSCs). However, its application is severely restrained due to unfavorable interfacial reactions and insufficient charge carrier extraction. Herein, a multifunctional modification at the NiO /perovskite interface is developed via introducing fluorinated ammonium salt ligand to synthetically solve the obstacles.

Targeting RNA N6-methyladenosine to synergize with immune checkpoint therapy.

Cancer immunotherapy, especially immune checkpoint therapy, has revolutionized therapeutic options by reactivating the host immune system. However, the efficacy varies, and only a small portion of patients develop sustained antitumor responses. Hence, illustrating novel strategies that improve the clinical outcome of immune checkpoint therapy is urgently needed.

Dual Optimization of Bulk and Interface via the Synergistic Effect of Ligand Anchoring and Hole Transport Dopant Enables 23.28% Efficiency Inverted Perovskite Solar Cells.

The crystalline morphology of perovskite film plays a key role in determining the stability and performance of perovskite solar cells (PSCs). In addition, the work function and conductivity of hole transport layer (HTL) have a great influence on the effciency of PSCs. Here, we develop a synergistic doping strategy to fabricate high-performance inverted PSCs, doping a functional nanographene (C-AHM) into the poly[bis(4-phenyl)(2,4,6-trimethylphenyl)amine (PTAA) HTL, thus forming an HTL with higher conductivity, lower roughness, and frontier energy levels matching the perovskite absorber work function.

Identification and validation of an m6A-related gene signature to predict prognosis and evaluate immune features of breast cancer.

Breast cancer is the most prevalent cancer, and it is accompanied by high heterogeneity. N6-methyladenosine (m6A) modification significantly contributes to breast cancer tumorigenesis and progression. However, how m6A-related genes affect the clinical outcomes and tumor immune microenvironment (TIME) of breast cancer is largely unknown.

CircRNA-CREIT inhibits stress granule assembly and overcomes doxorubicin resistance in TNBC by destabilizing PKR.

Background: Circular RNAs (circRNAs) represent a novel type of regulatory RNA characterized by high evolutionary conservation and stability. CircRNAs are expected to be potential diagnostic biomarkers and therapeutic targets for a variety of malignancies. However, the regulatory functions and underlying mechanisms of circRNAs in triple-negative breast cancer (TNBC) are largely unknown.

Integrated Ideal-Bandgap Perovskite/Bulk-Heterojunction Solar Cells with Efficiencies > 24.

Here, the authors report a highly efficient integrated ideal-bandgap perovskite/bulk-heterojunction solar cell (IPBSC) with an inverted architecture, featuring a near infrared (NIR) polymer DTBTI-based bulk-heterojunction (BHJ) layer atop guanidinium bromide (GABr)-modified FA MA Pb Sn I perovskite film as the photoactive layer. The IPBSC shows cascade-like energy level alignment between the charge-extractionlayer/perovskite/BHJ and efficient passivation effect of BHJ on perovskite. Thanks to the well-matched energy level alignment and high-quality ideal bandgap-based perovskite film, an efficient charge transfer occurs between the charge-extraction-layer/perovskite/BHJ.

Huaier Induces Immunogenic Cell Death CircCLASP1/PKR/eIF2α Signaling Pathway in Triple Negative Breast Cancer.

Triple-negative breast cancer (TNBC) is the most lethal breast cancer subtype owing to the lack of targeted therapeutic strategies. Immunogenic cell death (ICD), a modality of regulated cancer cell death, offered a novel option for TNBC augmenting tumor immunogenic microenvironment. However, few ICD-inducing agents are currently available.

Valproic Acid Inhibits Glial Scar Formation after Ischemic Stroke.

Introduction: Cerebral ischemia induces reactive proliferation of astrocytes (astrogliosis) and glial scar formation. As a physical and biochemical barrier, the glial scar not only hinders spontaneous axonal regeneration and neuronal repair but also deteriorates the neuroinflammation in the recovery phase of ischemic stroke.

Objectives: Previous studies have shown the neuroprotective effects of the valproic acid (2-n-propylpentanoic acid, VPA) against ischemic stroke, but its effects on the ischemia-induced formation of astrogliosis and glial scar are still unknown.

Cadmium Uptake and Translocation By Potato in Acid and Calcareous Soils.

Cadmium contamination of agricultural soils threatens food safety. The bioaccumulation (BAF) of Cd in potato tubers ranged from 0.69 to 1.

An in-situ defect passivation through a green anti-solvent approach for high-efficiency and stable perovskite solar cells.

Surface and grain boundary defects in halide perovskite solar cells are highly detrimental, reducing efficiencies and stabilities. Widespread halide anion and organic cation defects usually aggravate ion diffusion and material degradation on the surfaces and at the grain boundaries of perovskite films. In this study, we employ an in-situ green method utilizing nontoxic cetyltrimethylammonium chloride (CTAC) and isopropanol (IPA) as anti-solvents to effectively passivate both surface and grain boundary defects in hybrid perovskites.

The Key Regulator of Necroptosis, RIP1 Kinase, Contributes to the Formation of Astrogliosis and Glial Scar in Ischemic Stroke.

Necroptosis initiation relies on the receptor-interacting protein 1 kinase (RIP1K). We recently reported that genetic and pharmacological inhibition of RIP1K produces protection against ischemic stroke-induced astrocytic injury. However, the role of RIP1K in ischemic stroke-induced formation of astrogliosis and glial scar remains unknown.

Ghrelin modulates dopaminergic neuron formation and attention deficit hyperactivity disorder-like behaviors: From animals to human models.

Attention deficit hyperactivity disorder (ADHD) is one of the most prevalent psychiatric disorders in children. The orexigenic hormone ghrelin is important in neuroprotection and neurodevelopment, which may play an important role in psychopathogenesis of ADHD. This study aimed to systematically investigate the genomic and pharmacological manipulations of ghrelin functioning in ADHD-like symptoms in zebrafish models and validated the effects of ghrelin polymorphisms in human subjects with ADHD.

Association Between R353Q (rs6046) Polymorphism in Factor VII with Coronary Heart Disease.

A number of studies have showed the relationship between R353Q (rs6046) polymorphism in factor VII gene and coronary heart disease (CHD). However, the results remain controversial due to the limitations of the research objects and small sample size of individual study. We conducted this meta-analysis to validate the association between R353Q (rs6046) polymorphism and the risk of CHD.

Mechanism and consequences for avoidance of superparasitism in the solitary parasitoid Cotesia vestalis.

A parasitoid's decision to reject or accept a potential host is fundamental to its fitness. Superparasitism, in which more than one egg of a given parasitoid species can deposit in a single host, is usually considered sub-optimal in systems where the host is able to support the development of only a single parasitoid. It follows that selection pressure may drive the capacity for parasitoids to recognize parasitized hosts, especially if there is a fitness cost of superparasitism.

A dual function-enabled novel zwitterion to stabilize a Pb-I framework and passivate defects for highly efficient inverted planar perovskite solar cells.

A novel zwitterion named bethanechol chloride (BTCC) was introduced to simultaneously stabilize a Pb-I framework and passivate defects for efficient inverted perovskite solar cells. The BTCC-assisted device yielded an elevated power conversion efficiency of 20.45% with an open-circuit voltage of 1.

ALDH2 Gene rs671 Polymorphism May Decrease the Risk of Essential Hypertension.

Aldehyde dehydrogenase-2 (ALDH2) rs671 G>A polymorphism can influence the activity of ALDH2 and may be associated with the risk of essential hypertension (EH). Although many previous studies have explored such a relationship, the conclusion is still controversial.The PubMed, Embase, and China National Knowledge Infrastructure databases were searched on the ALDH2 gene and EH.

Highly Efficient and Stable GABr-Modified Ideal-Bandgap (1.35 eV) Sn/Pb Perovskite Solar Cells Achieve 20.63% Efficiency with a Record Small V Deficit of 0.33 V.

1.5-1.6 eV bandgap Pb-based perovskite solar cells (PSCs) with 30-31% theoretical efficiency limit by the Shockley-Queisser model achieve 21-24% power conversion efficiencies (PCEs).