Insights from pharmacovigilance and pharmacodynamics on cardiovascular safety signals of NSAIDs.

Background And Aim: Non-steroidal anti-inflammatory drugs (NSAIDs) are commonly used to treat fever, pain, and inflammation. Concerns regarding their cardiovascular safety have been raised. However, the underlying mechanism behind these events remains unknown.

iGlarLixi for type 2 diabetes: a systematic review and meta-analysis.

Objectives: To assess the efficacy and tolerability of iGlarLixi-a novel, fixed-ratio, soluble combination of insulin glargine and lixisenatide-for the treatment of type 2 diabetes (T2D).

Methods: The PubMed, Embase, Cochrane Library and ClinicalTrials.gov databases were searched from inception to November 15, 2023 to identify randomized controlled trials (RCTs) comparing iGlarLixi with a placebo or any other antidiabetic agent in adults with T2D.

Waterlogging in soil restricts the growth of seedlings and inhibits the accumulation of lignans and phenolic acids in thorns.

, commonly known as Chinese Zaojiao, has important economic value and medicinal compounds in its fruits and thorns, making it widely cultivated artificially in China. However, the available literature on the impact of waterlogging on the growth of seedlings and the accumulation of metabolite compounds in its thorns is limited. To address this knowledge gap, seedlings were planted in soil supplemented with pindstrup substrate, which enhances the water-holding capacity of the soil.

Design and performance analysis of a new inferior vena cava filter.

This study proposes a novel inferior vena cava filter (IVCF) design, "Lotus," aiming to enhance release stability and endothelialization. A catheter-filter-vessel model was established for IVCF property analysis, validated by comparing numerical simulations and in vitro tests. Lotus's mechanical properties were analyzed, and optimization suggestions are provided.

IDegLira for type 2 diabetes: a systematic review and meta-analysis.

Objectives: IDegLira is a novel fixed-ratio soluble combination of insulin degludec and the glucagon-like peptide-1 receptor agonist (GLP-1RA) liraglutide approved for type 2 diabetes (T2D) patients. Individual trials have assessed the clinical profile of IDegLira vs different comparators. We conducted a systematic review and meta-analysis to evaluate the efficacy and safety of IDegLira for T2D.

Misoriented high-entropy iridium ruthenium oxide for acidic water splitting.

Designing an efficient catalyst for acidic oxygen evolution reaction (OER) is of critical importance in manipulating proton exchange membrane water electrolyzer (PEMWE) for hydrogen production. Here, we report a fast, nonequilibrium strategy to synthesize quinary high-entropy ruthenium iridium-based oxide (M-RuIrFeCoNiO) with abundant grain boundaries (GB), which exhibits a low overpotential of 189 millivolts at 10 milliamperes per square centimeter for OER in 0.5 M HSO.

Controlling Surface Chemical Inhomogeneity of Ni P/MoNiP /MoP Heterostructure Electrocatalysts for Efficient Hydrogen Evolution Reaction.

Crystalline/amorphous phase engineering is demonstrated as a powerful strategy for electrochemical performance optimization. However, it is still a considerable challenge to prepare transition metal-based crystalline/amorphous heterostructures because of the low redox potential of transition metal ions. Herein, a facile H -assisted method is developed to prepare ternary Ni P/MoNiP /MoP crystalline/amorphous heterostructure nanowires on the conductive substrate.

Ultralow-iridium content NiIr alloy derivative nanochain arrays as bifunctional electrocatalysts for overall water splitting.

The development of low-cost and high-durability bifunctional electrocatalysts is of considerable importance for overall water splitting (OWS). This work reports the controlled synthesis of nickel-iridium alloy derivative nanochain array electrodes (NiIr NCs) with fully exposed active sites that facilitated mass transfer for efficient OWS. The nanochains have a self-supported three-dimensional core-shell structure, composed of a metallic NiIr core and a thin (5-10 nm) amorphous (hydr)oxide film as the shell (, IrO/NiIr and Ni(OH)/NiIr).

S-Scheme Porphyrin Covalent Organic Framework Heterojunction for Boosted Photoelectrochemical Immunoassays in Myocardial Infarction Diagnosis.

Cardiac troponin I (cTnI) is an extremely sensitive biomarker for early indication of acute myocardial infarction (AMI). However, it still remains a tough challenge for many newly developed cTnI biosensors to achieve superior sensing performance including high sensitivity, rapid detection, and resistance to interference in clinical serum samples. Herein, a novel photocathodic immunosensor toward cTnI sensing has been successfully developed by designing a unique S-scheme heterojunction based on the porphyrin-based covalent organic frameworks (p-COFs) and p-type silicon nanowire arrays (p-SiNWs).

Berberine attenuates sunitinib-induced cardiac dysfunction by normalizing calcium regulation disorder via SGK1 activation.

Sunitinib (SNT)-induced cardiotoxicity is associated with abnormal calcium regulation caused by phosphoinositide 3 kinase inhibition in the heart. Berberine (BBR) is a natural compound that exhibits cardioprotective effects and regulates calcium homeostasis. We hypothesized that BBR ameliorates SNT-induced cardiotoxicity by normalizing the calcium regulation disorder via serum and glucocorticoid-regulated kinase 1 (SGK1) activation.

S-Species-Evoked High-Valence Ni of the Evolved β-Ni(OH) Electrode for Selective Oxidation of 5-Hydroxymethylfurfural.

An efficient NiS -modified β-Ni(OH) electrode is reported for the selective oxidation reaction of 5-hydroxymethylfurfural (HMFOR) with excellent electrocatalytic 5-hydroxymethylfurfural (HMF) selectivity (99.4%), conversion (97.7%), and Faradaic efficiency (98.

Multiple regulation towards an all-in-one NiCuMo/MoO heterostructure for improving alkaline hydrogen oxidation.

Herein, we report a multiple regulation strategy towards an all-in-one NiCuMo/MoO heterostructure for the HOR, which exhibits ultrahigh HOR activity ( = 4.63 mA cm) and excellent durability for almost 24 h for the synergistic regulation of Mo and Cu on the Ni electrode. This study provides a new strategy for designing efficient non-noble metal-based HOR catalysts.

Worm-like porous and defect-structured cadmium stannate photoanodes for enhanced solar water oxidation.

The work aims to elucidate the importance of hybrid microwave annealing technology (HMA) in ultrafast fabrication of deficient cadmium stannate (CdSnO) photoanodes with a worm-like porous structure and significant enhancement of solar water oxidation performance and stability. Comparison of three synthetic routes and experimental characterization revealed that relative to conventional thermal annealing (CTA) or even with extra HMA for 5 min (optimal), direct HMA for only 8 min can form cubic CdSnO thin films of unique worm-like and highly porous nanostrucures with a large interfacial surface area, high degree of phase crystallinity and high-concentration defects. The obtained results from the photoluminescence spectra and the charge efficiency measurements collaboratively verified that compared to using CTA treatment solely, the HMA treatment is effective in significantly improving charge separation, recombination and transfer processes, mainly by an over 13.

A novel photoelectrochemical sensor based on SiNWs@PDA for efficient detection of myocardial infarction.

Based on the necessity and urgency of cardiac troponin I (cTnI) detection for the diagnosis of myocardial infarction, a novel unlabeled photoelectrochemical (PEC) immunosensor has been developed to detect cTnI rapidly and sensitively. Silicon nanowire arrays (SiNWs) were prepared metal-assisted chemical etching. To improve the stability and sensitivity towards cTnI sensing, the surface of silicon nanowire arrays were coated with polydopamine by an growth method.

Reinforced Layered Double Hydroxide Oxygen-Evolution Electrocatalysts: A Polyoxometallic Acid Wet-Etching Approach and Synergistic Mechanism.

Nickel-iron-based layered double hydroxides (NiFe LDHs) have attracted tremendous research and industrial interests for oxygen evolution reaction (OER) electrocatalysis. However, methodologies on simultaneous regulation of performance-influencing factors remain scarce and their real synergistic effects are not clear enough. Herein, a versatile polyoxometallic acids (POMs) etching approach is reported to ingeniously reconstruct NiFe LDH, including 3D morphological nanotailoring, Fe and α-Ni(OH) active species reconfiguration, creation of multiple Ni, Fe, and O vacancies, and intercalation of POM polyanionic clusters.

Polydopamine stabilizes silver nanoparticles as a SERS substrate for efficient detection of myocardial infarction.

Rapid and accurate detection of myocardial infarction (MI) can boost the patient's chance of survival. Surface enhanced Raman scattering (SERS) is an outstanding diagnostic technique because of its strong light stability, high resolution, and qualitative and quantitative analysis based on the characteristic fingerprint. However, its reliability, stability and specificity remain to be improved, especially in the quantitative analysis of serum samples.

Controlled preparation and gas sensitive properties of two-dimensional and cubic structure ZnSnO.

Two-dimensional (2D) ZnSnO is a promising candidate for future gas sensors due to its high chemical response and excellent electronic properties. However, the preparation of 2D ZnSnO nanosheets by utilizing soluble inorganic salts and nonorganic solvents remains a challenge. In this work, 2D ZnSnO was synthesized via a facile graphene oxide (GO)-assisted co-precipitation method, in which inorganic salts in the aqueous phase replaced metal organic salts in a non-aqueous system.

GDF-15 Suppresses Atherosclerosis by Inhibiting oxLDL-Induced Lipid Accumulation and Inflammation in Macrophages.

The growth differentiation factor-15 (GDF-15) may be involved in atherosclerosis. However, the role of GDF-15 in atherosclerosis remains unclear. The main goal of this study was to verify the role and mechanism of GDF-15 in atherogenesis.

Air-Stable Mn doped CuCl/CuO Hybrid Triquetrous Nanoarrays as Bifunctional Electrocatalysts for Overall Water Splitting.

The development of highly efficient non-precious metal catalysts for oxygen evolution reaction (OER) and hydrogen evolution reaction (HER) is key for large-scale hydrogen evolution through water splitting technology. Here, we report an air-stable Cu-based nanostructure consisting of Mn doped CuCl and CuO (CuCl/CuO(Mn)-NF) as a dual functional electrocatalyst for water splitting. CuCl is identified as the main active component, together with Mn doping and the synergistic effect between CuCl and CuO are found to make responsibility for the excellent OER and HER catalytic activity and stability.

Recent Advances on MOF Derivatives for Non-Noble Metal Oxygen Electrocatalysts in Zinc-Air Batteries.

Oxygen electrocatalysts are of great importance for the air electrode in zinc-air batteries (ZABs). Owing to the high specific surface area, controllable pore size and unsaturated metal active sites, metal-organic frameworks (MOFs) derivatives have been widely studied as oxygen electrocatalysts in ZABs. To date, many strategies have been developed to generate efficient oxygen electrocatalysts from MOFs for improving the performance of ZABs.

A Zeolitic-Imidazole Framework-Derived Trifunctional Electrocatalyst for Hydrazine Fuel Cells.

Hydrazine fuel cells are promising sustainable power sources. However, the high price and limited reserves of noble metal catalysts that promote the sluggish cathodic and anodic electrochemical reactions hinder their practical applications. Reflecting the enhanced diffusion and improved kinetics of nanostructured non-noble metal electrocatalysts, we report an efficient zeolitic-imidazole framework-derived trifunctional electrocatalyst for hydrazine oxidation, oxygen, and hydrogen peroxide reduction.

Pd nanocrystal sensitization two-dimension porous TiO for instantaneous and high efficient H detection.

Hydrogen (H) molecules are easy to leak during production, storage, transportation and usage. Because of their flammability and explosive nature, quick and reliable dectection of H molecule is of great significance. Herein, an excellent H gas sensor has been realized based on Pd nanocrystal sensitized two-dimensional (2D) porous TiO (Pd/TiO).

The optimal structural analysis of cobalt-chromium alloy (L-605) coronary stents.

A coronary stent is a conventional medical device used in percutaneous coronary intervention (PCI), and its mechanical properties have become one of the critical factors to determine the effect of surgical treatment. Based on the existing cobalt-chromium (CO-Cr) alloy L605 coronary stent, this paper established an integrated finite element model of the stent-balloon-compression shell to simulate the stent bundle expansion test and crush resistance test with parallel plates. We verified the accuracy of the analytical model by comparing the simulation results with experimental results.

Predictive role of perioperative neutrophil to lymphocyte ratio in pediatric congenital heart disease associated with pulmonary arterial hypertension.

Background: We aimed to explore the relationship between the neutrophil to lymphocyte ratio (NLR) and the early clinical outcomes in children with congenital heart disease (CHD) associated with pulmonary arterial hypertension (PAH) after cardiac surgery.

Methods: A retrospective observational study involving 190 children from January 2013 to August 2019 was conducted. Perioperative clinical and biochemical data were collected.