Chimeric Antigen Receptor T Cells Targeting CD19 and GCC in Metastatic Colorectal Cancer: A Nonrandomized Clinical Trial.

Importance: Chimeric antigen receptor (CAR) T-cell therapy (CART) has transformed the treatment landscape of hematologic cancer, but has negligible effects for adult solid cancers. In this trial, an autologous CAR T-cell product demonstrated antitumor activity in heavily pretreated patients with metastatic colorectal cancer (mCRC).

Objective: To evaluate the safety and efficacy of guanylate cyclase-C (GCC19) CART in participants with metastatic colorectal cancer (mCRC).

Ultrasound super-resolution imaging for differential diagnosis of breast masses.

Objective: Ultrasound imaging has been widely used in breast cancer screening. Recently, ultrasound super-resolution imaging (SRI) has shown the capability to break the diffraction limit to display microvasculature. However, the application of SRI on differential diagnosis of breast masses remains unknown.

Coding region prediction based on a universal DNA sequence representation method.

Graphical representation of DNA sequences provides a simple and intuitive way of viewing, anchoring, and comparing various gene structures, so a simple and non-degenerate method is attractive to both biologists and computational biologists. In this study, a universal graphical representation method for DNA sequences based on S.S.