Sacubitril-Valsartan Compared With Enalapril for the Treatment of Heart Failure: A Decision-Analytic Markov Model Simulation in China.

Objectives: Heart failure with reduced ejection fraction (HFrEF) is a major health concern globally due to high mortality rates, frequent hospitalization and considerable medical expenditure. The prevalence of HFrEF is steadily rising in Asian countries, and populous, developing countries like China are facing a significant socio-economic burden as a result. Sacubitril-valsartan (Sac-Val) is currently a class I recommendation for treating HFrEF in major guidelines, although it has not been pharmaco-economically evaluated in China.

Attitudes and perceptions regarding antimicrobial use and resistance among medical students in Central China.

Objectives: Senior medical students, who are future doctors, should be prepared to use antimicrobials appropriately and will be important partners in antimicrobial stewardship. This survey was designed to investigate the attitudes and perceptions of senior medical students regarding antimicrobial use and resistance.

Methodology: We performed a multi-center survey involving a questionnaire handed out to all fourth year medical students from five representative teaching hospitals in Central China.

In vitro and in vivo studies on ocular vitamin A palmitate cationic liposomal in situ gels.

N-trimethyl chitosan (TMC) with different degree of quaternization (DQ) as the coating materials, vitamin A palmitate (VAP)-loaded cationic liposomes dispersed in thermo-sensitive in situ gels (ISG) with poloxamer 407 (P407) as the base were prepared in this study. VAP-loaded liposomes (VAPL) were prepared using a film dispersion method followed by TMC-coating with DQ of 20%, 40% and 60% (TMC20, TMC40 and TMC60), respectively, then dispersed in P407 solution to obtain TMC-coated VAPL ISG. The in vitro properties of the system including morphology, size, zeta potential, entrapment efficiency, drug release and ocular retention were investigated.

Study on the mechanisms of chitosan and its derivatives used as transdermal penetration enhancers.

The efficacy of chitosan (CS) and its derivatives used as transdermal penetration enhancers has been confirmed in our previous research. This study investigated the mechanisms of penetration enhancement by CS and its derivatives, i.e.

Transdermal permeation enhancement of N-trimethyl chitosan for testosterone.

The aim of this study was to evaluate the transdermal permeation enhancement of N-trimethyl chitosan (TMC) with different degrees of quaternization (DQ). TMCs with DQ of 40 and 60% (TMC40 and TMC60) were synthesized and characterized by (1)H NMR. Testosterone (TS) used as an effective drug, four different gels were prepared without enhancer, with 5% TMC40, 5% TMC60 or 2% Azone, respectively as enhancer.

[Study on the pharmacokinetics and bioavailability of syringic acid in rabbits].

Objective: To study the pharmacokinetics and bioavailability of syringic acid(SA) in rabbits by HPLC.

Method: After the rabbits were injected SA injection via ear vein and peritoneal cavity, blood was collected also via ear vein at different time-point. Then the concentration of SA in blood was determined by HPLC and the concentration-time curve was mapped to simulate a compartment model.