The mechanism of oxymatrine on atopic dermatitis in mice based on SOCS1/JAK-STAT3 pathway.

Based on the suppressor of cytokine signaling 1 (SOCS1)/Janus kinase (JAK)/signal transducer and activator of transcription 3 (STAT3) pathway, the mechanism of oxymatrine in the treatment of atopic dermatitis (AD) was preliminarily explored in this study. C57BL/6 mice were induced to establish AD model by smearing carbotriol (MC903) on their back. The AD mice were randomly divided into model group, oxymatrine groups with three dosages (25, 50 and 100 mg/kg), ( = 10).

Ultrahigh mechanical flexibility induced superior piezoelectricity of InSeBr-type 2D Janus materials.

InSeBr-Type monolayers, ternary In(Se,S)(Br,Cl) compounds, are typical two-dimensional (2D) Janus materials and can be exfoliated from their bulk crystals. The structural stability, electronic properties, mechanical flexibility, and intrinsic piezoelectricity of these InSeBr-type 2D Janus monolayers are comprehensively investigated by first-principles calculations. Our calculations show that the stable InSeBr-type monolayers exhibit ultrahigh mechanical flexibility with low Young's moduli.

Composition, Antivirulence Activity, and Active Property Distribution of the Fruit of Terminalia chebula Retz.

The fruit of Terminalia chebula Retz., or Tibet Olive, is widely used as a food supplement in China. It possesses some natural antimicrobial properties; however, its chemical composition and antivirulence effects have not been identified.

Tuning Ion Transport through a Nanopore by Self-Oscillating Chemical Reactions.

Ion transport in nanofluidic devices and biological ion channels are highly dependent on the local environmental conditions in the electrolyte solution. Many life processes in living systems are in dynamic electrolyte solutions, and many of them are self-oscillated. Tuning ion transport through a nanofluidic diode by the self-oscillating chemical reactions is demonstrated by modeling the electrokinetic ion transport process with a validated continuum model, which includes the time-dependent Poisson-Nernst-Planck equations for the ionic mass transport of multiple ionic species with both volumetric and surface chemical reactions, and Stokes equations for the flow field.

Multi-Stage Particle Separation based on Microstructure Filtration and Dielectrophoresis.

Particle separation is important in chemical and biomedical analysis. Among all particle separation approaches, microstructure filtration which based particles size difference has turned into one of the most commonly methods. By controlling the movement of particles, dielectrophoresis has also been widely adopted in particle separation.