Publications by authors named "Xiansheng Lu"
Article Synopsis
- Researchers are studying how combining immunotherapy and radiotherapy (RT) affects cancer tumors, especially focusing on the tumor's environment and immune response.
- They collected tumor samples from a patient with stomach cancer to see how different types of cells changed during RT using special techniques.
- Their findings showed that while RT increases some immune cells, it also lowered the presence of others, suggesting careful planning is needed for effective cancer treatments combining RT and immunotherapy.
Article Synopsis
- This study investigates the effectiveness of immune checkpoint blockades combined with chemotherapy in metastatic gastric cancer (mGC) and introduces a TMEscore model to evaluate the tumor microenvironment (TME) as a potential biomarker for treatment response.* -
- A total of 86 tumor samples were analyzed from patients in a multi-center trial, showing that a higher TMEscore correlated with better treatment responses (31.4% overall response rate), with TMEscore-high patients achieving a 59% response rate and improved survival outcomes.* -
- The TMEscore outperformed other biomarkers like MSI and CPS for predicting patient responses, indicating its potential as a reliable tool for identifying mGC patients who could benefit from ICB and
Article Synopsis
- Hepatocellular carcinoma (HCC) is a serious and prevalent tumor, and this study explores the role of the tumor suppressor candidate TUSC3 in its development and progression.
- The researchers found that lower levels of TUSC3 in HCC tissues led to larger tumors and worse outcomes, while increasing TUSC3 levels had the opposite effect, reducing tumor growth and spread.
- TUSC3 influences HCC by regulating the epithelial-mesenchymal transition (EMT) via its interaction with the glycoprotein LIPC and the AKT signaling pathway.
Esophageal squamous cell carcinoma (ESCC) is one of the most prevalent cancers worldwide. There is a critical need to identify new mechanisms that contribute to ESCC progression. Reticulocalbin3 (RCN3) is mainly located in the endoplasmic reticulum and Ca -binding protein containing EF-hands.
View Article and Find Full Text PDFBackground: Serine/arginine-rich splicing factor 9 (SRSF9) is a classical RNA-binding protein that is essential for regulating gene expression programs through its interaction with target RNA. Whether SRSF9 plays an essential role in colorectal cancer (CRC) progression and can serve as a therapeutic target is largely unknown. Here, we highlight new findings on the role of SRSF9 in CRC progression and elucidate the underlying mechanism.
View Article and Find Full Text PDFEndothelial lipase (LIPG/EL) performs fundamental and vital roles in the human body, including cell composition, cytokine expression, and energy provision. Since LIPG predominantly functions as a phospholipase as well as presents low levels of triglyceride lipase activity, it plays an essential role in lipoprotein metabolism, and involves in the metabolic syndromes such as inflammatory response and atherosclerosis. Cytokines significantly affect LIPG expression in endothelial cells in many diseases.
View Article and Find Full Text PDFTumor suppressor candidate 3 (TUSC3) is a coding gene responsible for N-glycosylation of many critical proteins. TUSC3 gene plays an oncogenic role in colorectal cancer (CRC), however, the role of TUSC3 in drug resistance of CRC is still unclear. The aim of this study is to investigate the biological function and molecular mechanism of TUSC3 in CRC drug resistance.
View Article and Find Full Text PDFBackground: Esophageal squamous cell carcinoma (ESCC) is one of the most prevalent cancers worldwide. Due to its high morbidity and mortality rates, it is urgent to find a molecular target that contributes to esophageal carcinogenesis and progression. In this research, we aimed to investigate the functions of Latent transforming growth factor β binding protein 1(LTBP1) in ESCC progression and elucidate the underlying mechanisms.
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