Publications by authors named "Xiansen Wei"
Article Synopsis
- The study investigated the effectiveness of a lower dose of tolvaptan for treating autosomal dominant polycystic kidney disease (ADPKD) among Chinese patients, as there was limited information on optimal dosing for this population.
- Conducted as a retrospective cohort study, 43 patients were treated with tolvaptan for at least 12 months, starting with a morning/evening dose of 7.5 mg, and adjustments were made based on individual responses.
- Results showed a significant improvement in kidney function (eGFR) and reduced kidney volume growth after 12 months of treatment, with manageable side effects primarily consisting of mild thirst reported by about half of the participants.
Objective: Accumulating experimental evidence has shown that resveratrol supplementation is effective for treating diabetic nephropathy (DN) in animal models. In this systematic review and meta-analysis, we assessed the effects and multiple mechanisms of resveratrol in animal models of DN.
Methods: Before September 2023, preclinical literature was systematically searched and screened across PubMed, Web of Science, EMBASE, and the Cochrane Library.
Background: Membranous nephropathy (MN) is an autoimmune disease and represents the most prevalent type of renal pathology in adult patients afflicted with nephrotic syndrome. Despite substantial evidence suggesting a possible link between MN and cancer, the precise underlying mechanisms remain elusive.
Methods: In this study, we acquired and integrated two MN datasets (comprising a single-cell dataset and a bulk RNA-seq dataset) from the Gene Expression Omnibus database for differential expression gene (DEG) analysis, hub genes were obtained by LASSO and random forest algorithms, the diagnostic ability of hub genes was assessed using ROC curves, and the degree of immune cell infiltration was evaluated using the ssGSEA function.
Objectives: Postprandial hypotension (PPH) is a unique clinical phenomenon in the elderly, but its underlying pathogenesis has not been completely elucidated, and drug treatment is still in clinical exploratory stage. The aim of the study was to evaluate the relationship between the fall in postprandial blood pressure and splanchnic blood flow, and to provide a theoretical basis for the treatment of PPH by taking acarbose.
Patients And Methods: The study included 20 elderly inpatients diagnosed with PPH concomitant with abnormal glucose metabolism at stable condition.