Publications by authors named "Xianrun Hu"
Effects and mechanisms of harmine on ameliorating ethanol-induced memory impairment.
J Ethnopharmacol
January 2025
Ethnopharmacological Relevance: Peganum harmala L., a traditional Uyghur ethnic medicine widely used in China, is commonly used in the treatment of conditions such as hemiplegia, forgetfulness, cough, and asthma. Harmine and other β-carboline alkaloids, one of the main active ingredients in P.
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- Zuojin Pill (ZJP) is a traditional Chinese medicine primarily used for gastric disorders, composed of Rhizoma Coptidis and Euodiae Fructus in a 6:1 ratio.
- The study developed a method using UHPLC-Q-TOF-MS to analyze the in vivo metabolism and distribution of protoberberine alkaloids (PBAs) and indole alkaloids (IDAs) in rats, identifying 33 compounds, including 7 primary alkaloids and 26 metabolites.
- The findings revealed that these alkaloids and metabolites preferentially localized in the stomach and interacted strongly with key targets associated with gastritis, providing insights for future research into ZJP's therapeutic mechanisms.
Ethnopharmacological Relevance: Alzheimer's disease (AD) is a progressive developmental neurodegenerative disease that primarily develops in old age. Memory impairment is an important manifestation of AD. It has been demonstrated that inflammation and oxidative stress are important mediators in the development and progression of AD.
View Article and Find Full Text PDFEthnopharmacological Relevance: Fufangmuniziqi formula (FFMN), a traditional Uyghur medicine used in China, is derived from an ancient Uyghur medical book and consists of 13 herbs. The herbs of FFMN, such as Peganum harmala L., Glycyrrhiza uralensis Fisch.
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