Publications by authors named "Xianqin Zhou"
Article Synopsis
- Patients with schizophrenia experience heightened inflammation during acute episodes, and the neutrophil/lymphocyte ratio (NLR) could serve as a potential biomarker for these exacerbations.
- A study involving 651 participants (including both healthy controls and various patient groups) analyzed inflammatory indices and found that NLR was significantly higher in drug-free and medicated patients during acute phases compared to healthy individuals.
- While NLR correlated with disease duration and mood stabilizer use, the platelet/lymphocyte ratio (PLR) and monocyte/lymphocyte ratio (MLR) showed no significant differences among the patient groups or with healthy controls.
Many studies have investigated the changes of immune cells and proinflammatory cytokines in patients with acute schizophrenia, but few studies have investigated the functional phenotypes of immune cells and the expression rate of programmed cell death protein 1 (PD-1)/ programmed cell death-Ligand 1 (PD-L1). The aim of this study was to investigate the extent of immune cells activation, PD-1/PD-L1 expressions, and altered cytokine levels in drug-naïve schizophrenia patients with acute-phase. 23 drug-naïve schizophrenia patients in acute-phase and 23 healthy individuals were enrolled in this study as experimental and control groups, separately.
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