Study on the mechanism of Panax notoginseng-Salvia miltiorrhiza herb pair on invigorating blood circulation and eliminating blood stasis by blocking the conversion of arachidonic acid to prostaglandin.

We combined untargeted and targeted metabolomics to explore the mechanism of blood circulation and blood stasis activation in the traditional Chinese herb pair Panax notoginseng-Salvia miltiorrhiza (PS). In this study, the right hind limb of SD rats was struck by a 1 kg weight, causing traumatic blood stasis (TBS) model, then the rats were gavaged with PS (at ratios of 1:0, 0:1, 3:1, 1:1, and 1:3) for 5 consecutive days. At the end of treatment, blood samples were collected for blood rheology and metabolomics analysis, and muscle tissues of injured limbs were used for HE staining and q-PCR analysis.

The association between insulin resistance and vascularization of thyroid nodules.

Context: Insulin resistance (IR) is an important factor for the growth and progression of thyroid nodules, which might be associated with the distribution, construction, and density of nodular vascularization.

Objective: The objective of the study was to explore the association between IR and the vascularization of thyroid nodules.

Design And Setting: A cross-sectional, population-based study was conducted in Nanjing, China, from June to November 2011.