In situ synthesis of ultrafine CuO on layered double hydroxide for electrochemical detection of S-nitrosothiols.

The identification and quantitation of S-nitrosothiols (RSNO) has aroused enormous levels of attention, due to RSNO have many roles in vivo. Here, we synthesized the nanocomposites of ultrafine CuO/layered double hydroxide (u-CuO/LDH) by the in situ topotactic reduction of a Cu-containing LDH with ascorbic acid under gentle conditions and applied these u-CuO/LDH to detect and monitor RSNO. Electrochemical signals of u-CuO/LDH exhibited a wide N-acetyl-S-nitrosopenicillamine detection range from 5.