Cascade Self-Generation of Carbon Monoxide Triggered by Photoinduced Holes for Efficient Hypoxic Tumors Therapy.

It still remains challenging to design multifunctional therapeutic reagents for effective cancer therapy under a unique tumor microenvironment including insufficient endogenous HO and O2, low pH, and a high concentration of glutathione (GSH). In this work, a CO-based phototherapeutic system triggered by photogenerated holes, which consisted of ionic liquid (IL), the CO prodrug Mn(CO), and iridium(III) porphyrin (IrPor) modified carbonized ZIF-8-doped graphitic carbon nitride nanocomposite (IL/ZCN@Ir(CO)), was designed for cascade hypoxic tumors. Upon light irradiation, the photogenerated holes on IL/ZCN@Ir(CO) oxidize water into HO, which subsequently induces Mn(CO) to release CO.

The Nonlinear Dynamics of a MEMS Resonator with a Triangular Tuning Comb.

The nonlinear dynamic response of a MEMS resonator with a triangular tuning comb is studied. The motion equation with dis-smooth tuning electrostatic force is derived according to Newton's second law. The analytical solution of the periodic response is obtained using the harmonic balance method and section integral method.

pH-Responsive Multifunctional Nanoplatforms with Reactive Oxygen Species-Controlled Release of CO for Enhanced Oncotherapy.

Recently, various nanomaterials have drawn increasing attention for enhanced tumor therapy. However, a lack of tumor uptake and insufficient generation of cytotoxic agents have largely limited the antitumor efficacy in vivo. Herein, a multifunctional nanoplatform (IL@CPPor(CO)) was constructed with pH-responsive copper peroxide nanoparticles (CPNP) that are capable of self-supplying HO, a radical-sensitive carbonic oxide (CO) donor (Fe(CO)), photosensitizer Iridium(III) meso-tetra (-methyl-4-pyridyl)porphyrin pentachloride (IrPor), and ionic liquid (IL) for enhanced oncotherapy.

Sensitive Electrochemical Sensor for Glycoprotein Detection Using a Self-Serviced-Track 3D DNA Walker and Catalytic Hairpin Assembly Enzyme-Free Signal Amplification.

Approaches for the detection of targets in the cellular microenvironment have been extensively developed. However, developing a method with sensitive and accurate analysis for noninvasive cancer diagnosis has remained challenging until now. Here, we reported a sensitive and universal electrochemical platform that integrates a self-serviced-track 3D DNA walker and catalytic hairpin assembly (CHA) triggering G-Quadruplex/Hemin DNAzyme assembly signal amplification.

Ionic liquid functionalized metal-organic framework nanowires for sensitive and real-time electrochemical monitoring of nitric oxide released from living cells.

Sensitive, selective, and real-time detection of nitric oxide (NO) is still challenging due to its rapid diffusion, short half-life, and low concentration in living systems. Herein, we synthesized well-defined ultralong metal-organic framework nanowires (MOFNWs) that were further uniformly covered with gold nanoparticle (AuNPs) and ionic liquids (ILs) and applied these NWs to detect and monitor NO released from living cells. In this system, ILs and AuNPs act as excellent catalysts for electrochemical oxidation of NO.

ROS generation strategy based on biomimetic nanosheets by self-assembly of nanozymes.

Reactive oxygen species (ROS) play an important role in physiology and have been applied in tumor therapy. However, insufficient endogenous HO and hypoxia in cancer cells can lead to limited ROS production and poor therapeutic efficacy. Herein, we develop a biomimetic nanosheet material based on the self-assembly of nanozymes that could supply HO under acidic conditions and catalyze a cascade of intracellular biochemical reactions to produce ROS under both normoxic and hypoxic conditions without any external stimuli.

Electrochemically classifying DNA structure based on the small molecule-DNA recognition.

Herein, we reported the differential binding ability of aminoglycosides to DNA structures using electrochemical method through principal component analysis (PCA) to classify different DNA secondary structures and understand the link between secondary structure and DNA conformation. In these analyses, the DNA with different secondary structure motifs: bulge, internal loop, hairpin loop and stem loop were designed. The aminoglycosides as receptors were modified on the surface of electrode.

Versatile metal-organic frameworks as a catalyst and an indicator of nitric oxide.

The imaging of nitric oxide (NO) and its donors is crucial to explore NO-related physiological and pathological processes. In this work, we demonstrate the use of Cu-based metal-organic frameworks (Cu-MOFs) as nanoprobes for NO detection and as a catalyst for the generation of NO from the biologically occurring substrate, S-nitrosothiols (RSNOs). The paramagnetic Cu in the MOFs could quench the luminescence of triphenylamine; Cu-MOFs only exhibited weak emission at 450 nm.

Porphyrin decorated CuO nanocrystals for electroanalytical detection of S-Nitrosothiols.

S-nitrosothiols (RSNO) as the potential nitric oxide (NO) storage, transfer and delivery vehicles under physiological condition have been identified as important in a number of disease states. However, a detection and quantification of RSNO method with simple and sensitive in biological media is currently lacking. A novel electrochemical sensing platform based on ionic liquid (IL) and copper porphyrin (PorCu) decorated cuprous oxide (CuO) nanocomposites was developed to detect RSNO under physiological condition.

Ultrasensitive electrochemical biosensor for protein detection based on target-triggering cascade enzyme-free signal amplification strategy.

Herein, a cost-effective, simple and sensitive electrochemical sensing platform was established based on aptamer - target recognition and target-triggering signal amplification strategy for protein detection. Due to the high affinity between the aptamer and target, the assistant DNA1 (a1) could release from a1-aptamer duplex and trigger the following DNA circuits. The strand displacement and branch migration reaction brought assistant DNA3 (a3) released.

Understanding the Performance of Metal-Organic Frameworks for Modulation of Nitric Oxide Release from S-Nitrosothiols.

S-Nitrosothiols (RSNOs) which are important intermediates in circulating reservoirs of nitric oxide (NO), transport and numerous NO signaling pathways play intricate roles in the etiology of several pathologies. However, it is still a challenge to control the release of NO from nitrosylated compounds under physiological pH. In this paper, for the first time, we report the catalytic activity and kinetic study for the modulation of NO release from RSNOs by an array of metal-organic frameworks (MOFs) (M-MOF (M'); M=Zr, Cu; and M'=Cu, Pd, no metal) under physiological conditions via time-dependent absorbance spectra.

Electrochemical biosensor based on singlet oxygen generated by molecular photosensitizers.

Here a sensing strategy with the integration of photosensitizer and electrochemical analysis was present. The photosensitizer, Zinc(II) tetraphenylporphyrin (ZnTCPP), was functionalized graphene oxide (GO) to form complex (ZnTCPP/GO) as the electrode material and generated singlet-oxygen (O) in the presence of air under light illumination. Due to the special electronic structure of O, hydroquinone (HQ) could react with O to produce electrochemically-detectable products, benzoquinone (BQ).