Subsequently to the publication of the above paper, an interested reader drew to the authors' attention that, concerning the flow cytometric plots shown in Fig. 5A and B on p. 2572, each figure part contained a pair of duplicated data panels; specifically, the panels depicting the 'NC/5‑FU' and the 'shTRIM11/Gemcitabine' experiments in Fig 5A (MCF‑7 cells), and the 'NC/Paclitaxel' and 'shTRIM11/Adriamycin' experi-ments in Fig.
View Article and Find Full Text PDFBreast cancer, an increasing health problem worldwide, is the second major cause of cancer‑associated mortality in females. Studies have focused on the pathogenesis of breast cancer for decades, but the underlying mechanisms have not been fully elucidated. Tripartite motif‑containing 11 (TRIM11), a novel oncogene that was recently identified, was reported to function in various types of cancer, including ovarian and lung cancer.
View Article and Find Full Text PDFBACKGROUND STAT3 has emerged as a novel potential target for sorafenib, a multikinase inhibitor, in the context of cancer therapy. ARHGAP24 is a Rac-specific Rho GTPase-activating protein (Rho GAP), which can convert Rho GTPases to an inactive state. It has been proved to be an oncosuppressor protein in renal cancer.
View Article and Find Full Text PDFDexamethasone is widely used in multiple myeloma (MM) for its cytotoxic effects on lymphoid cells. However, many MM patients are resistant to dexamethasone, although some can benefit from dexamethasone treatment. In this study, we noted that ω-3 polyunsaturated fatty acids (PUFAs) enhanced the dexamethasone sensitivity of MM cells by inducing cell apoptosis.
View Article and Find Full Text PDFActa Crystallogr Sect E Struct Rep Online
January 2012
In the title compound, [Cu(CH(3)CO(2))(2)(C(9)H(7)N(3))(H(2)O)](n), the Cu(II) ion is penta-coordinated in a square-pyramidal geometry. The N atoms of the two chelating symmetry-related 5-(pyridin-3-yl)pyrimidine ligands and the O atoms of the two monodentate acetate anions are nearly coplanar, with a mean deviation from the least-squares plane of 0.157 (2) Å and the Cu(II) ion is displaced by 0.
View Article and Find Full Text PDFThe title compound, [Zn(C(9)H(7)N(3))(2)(H(2)O)(4)](CF(3)O(3)S)(2), contains an octahedral [ZnL(2)(H(2)O)(4)](2+) cationic complex with trans geometry (Zn site symmetry -1), and each 5-(3-pyridyl)pyrimidine (L) ligand is coordinated in a monodentate fashion through the pyridine N atom. In the extended structure, these complexes, with both hydrogen-bond acceptor (pyrimidine) and donor (H(2)O) functions, are linked to each other by intermolecular water-pyrimidine O-H···N hydrogen-bonding interactions, resulting in a double chain along the crystallographic a axis. The trifluoromethanesulfonate anions are integrated into the chains via O-H···O hydrogen bonds between the coordinated water and sulfonate O atoms.
View Article and Find Full Text PDFActa Crystallogr Sect E Struct Rep Online
April 2009
In the title compound, [NiCl(2)(C(10)H(10)N(2))(4)], the Ni(II) ion is located on an inversion center being coordinated by four N atoms from two pairs of symmetry-related 1-benzyl-1H-imidazole ligands and two chloride anions in a distorted octa-hedral geometry. Weak inter-molecular C-H⋯Cl hydrogen bonds link the mol-ecules into layers parallel to the ab plane.
View Article and Find Full Text PDFActa Crystallogr Sect E Struct Rep Online
November 2009
In the title mol-ecule, C(20)H(21)N(3)O(2), the benzene ring forms dihedral angles of 80.8 (1) and 83.5 (1)° with the two terminal pyridine rings.
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