Novel oxidative stress-related prognostic biomarkers for melanoma associated with tumor metastasis.

Skin cutaneous melanoma (SKCM) is a prevalent skin cancer whose metastatic form is dangerous due to its high morbidity and mortality. Previous studies have systematically established the vital role of oxidative stress (OS) in melanoma progression. This study aimed to identify prognostic OS genes closely associated with SKCM and illustrate their potential mechanisms.

Anti-cancer targets of formononetin and molecular mechanisms in osteosarcoma: Findings of bioinformatic and experimental assays.

In current study, a bioinformatic-based network pharmacology was used to identify the osteosarcoma (OGS)-pathological targets and formononetin (FN)-treated targets before the main core predictive biotargets were screened. In addition, all core targets were selected through a number of bioinformatic databases, followed by identification of predominant biological processes and signalling pathways of FN anti-OGS. Further, top three core targets of FN anti-OGS were determined as oestrogen receptor 1 (ESR1), tumour protein p53 (TP53), receptor tyrosine-protein kinase erbB-2 (ERBB2) respectively.

In vitro and in vivo studies of antiosteosarcoma activities of formononetin.

Osteogenic sarcoma (OGS) is a primary bone cancer, characterized by aggressive neoplasm from mesenchymal oncogenesis. However, the clinical therapeutic regimen against OGS is limited. Therefore, potential medication warrants to be further developed.

Minimally invasive versus open transforaminal lumbar fusion: a systematic review of complications.

Purpose: The aim of this study is to compare mTLIF vs. oTLIF with regard to peri-operative complications, operative time, estimated blood loss, fluoroscopic time, and the length of hospital stay.

Methods: The PubMed and EMBASE databases were searched for relevant articles reporting patients undergoing TLIF, and a comparison between mTILF and oTLIF was performed.

Control of crystallinity of hydrated products in a calcium phosphate bone cement.

In this study, a calcium phosphate cement (CPC), consisting of partially crystallized calcium phosphate (PCCP), was synthesized. X-ray diffraction (XRD), Fourier transform infrared spectrometry (FTIR) and scanning electronic microscope (SEM) were used to characterize the cement. The results showed that by changing the ratio of amorphous calcium phosphate (ACP) to PCCP in the cement, hydrated products of controllable crystallinity were obtained.