Dual-modal biosensor for mercuric ion detection based on CuO@CuS/D-TA COF heterojunction with excellent catalase-like, electrochemical and photoelectrochemical properties.

In this study, a dual-mode biosensor based on the heterojunction of CuO@CuS/D-TA COF was constructed for ultra-sensitive detection of Hg using both photoelectrochemical and electrochemical approaches. Briefly, a 2D ultra-thin covalent organic framework film (D-TA COF film) with excellent photoelectrochemical signals was prepared on ITO surfaces through an in situ growth method. Subsequently, the probe H1 was immobilized onto the biosensor via Au-S bonds.

Dextran-assisted ultrasonic exfoliation of two-dimensional metal-organic frameworks to evaluate acetylcholinesterase activity and inhibitor screening.

Acetylcholinesterase (AChE) is regarded as a biomarker of Alzheimer's disease (AD), and its inhibitors show great potential in AD therapy as AChE can increase the neurotoxicity of the amyloid component that induces AD. Because of this, it is crucial and significant to develop a simple and highly sensitive strategy to monitor AChE levels and screen highly efficient AChE inhibitors. Herein, we synthesize an ultrathin two-dimensional (2D) metal-organic framework (MOF) based on copper-catecholate (Cu-CAT) via dextran assisted ultrasound exfoliation, followed by construction of a sensitive sensor for the monitoring AChE and screening of its inhibitors.

Ultrasensitive Photoelectrochemical Biosensor Based on Novel Z-Scheme Heterojunctions of Zn-Defective CdS/ZnS for MicroRNA Assay.

The sensitive and accurate detection of microRNA (miRNA) has meaningful values for clinical diagnosis application as an early stage of tumor markers. Herein, a novel photoelectrochemical (PEC) biosensor was developed for the ultrasensitive and highly selective detection of microRNA-122 (miRNA-122) based on a direct Z-scheme heterojunction of Zn vacancy-mediated CdS/ZnS (CSZS-V). Impressively, the prepared Z-scheme heterojunction nanocomposite with defect level properties could make the photogenerated charges stay at the Zn vacancy defect levels and combine photogenerated holes in the valence bands of CdS, thus significantly achieving a better charge carrier separation efficiency and broadening the absorption of visible light and demonstrating 5-8 times enhancement of PEC response compared to single-component materials.

Construction of a Polarity-Switchable Photoelectrochemical Biosensor for Ultrasensitive Detection of miRNA-141.

As an early-stage tumor biomarker, microRNA (miRNA) has clinical application potential and its sensitive and accurate detection is significant for early tumor diagnosis. In this study, a photoelectrochemical (PEC) biosensing platform was fabricated for ultrasensitive miRNA-141 detection, which is based on a photocurrent polarity-switchable system using CdS quantum dots (QDs) in the presence of a 5,10,15,20-tetrakis (4-aminophenyl)-21H,23H-porphine (Tph-2H)-coated glassy carbon electrode (GCE). As an excellent photoactive material, Tph-2H has a narrow band gap that effectively gathers photoelectrons under visible light irradiation and improves the transfer ability of photogenerated electrons.

Seed-Morphology-Directed Synthesis of Concave Gold Nanocrystals with Tunable Sizes.

We report the fabrication of concave gold (Au) nanocrystals with a set of morphologies and controlled sizes via seeded growth. Starting with Au seeds with a well-defined morphology and uniform size, cubic and rodlike Au nanocrystals with a noticeable concave feature could be successfully obtained, respectively. We also track the growth process and record the shape evolution process.