Identification and Analysis of Phenolic Compounds in L. and Its Lipid-Lowering Activity In Vitro.

L. (VU), rich in polyphenols, is an important wild berry resource primarily distributed in extremely cold regions. However, the detailed composition of L.

GABA modulate NF-κB/NLRP3 pathways in electroacupuncture prevention of depression in CUMS rats.

Background: Our previous research has demonstrated that electroacupuncture (EA) has the potential to mitigate depression-like symptoms resulting from chronic stress. However, further investigation is required to fully understand the underlying mechanisms. The regulatory role of γ-aminobutyric acid type B (GABA) in synaptic plasticity and the involvement of NF-κB/NLRP3-mediated inflammation in the lateral habenula nucleus (LHb) are key factors in the development of depression.

Understanding the Antidepressant Mechanisms of Acupuncture: Targeting Hippocampal Neuroinflammation, Oxidative Stress, Neuroplasticity, and Apoptosis in CUMS Rats.

Depression is recognized globally as one of the most intractable diseases, and its complexity and diversity make treatment extremely challenging. Acupuncture has demonstrated beneficial effects in various psychiatric disorders. However, the underlying mechanisms of acupuncture's antidepressant action, particularly in depression, remain elusive.

Unveiling the antibacterial potential of anthocyanins - a comprehensive review on this natural plant extract.

With the gradual prohibition of antibiotic fungicides, it is of great significance to develop high-efficient, nontoxic and environmental-friendly antimicrobial agents. Anthocyanin is a natural plant polyphenol pigment which shows antibacterial, anti-inflammatory and antioxidant effects through inhibiting the synthesis of bacterial cell wall, interfering bacterial respiratory metabolism, and inducing bacterial autolysis. As a typical antibacterial agent, anthocyanins have been widely used in various fields, including biological pesticides or feed additives in agricultural production, anti-inflammatory and antibacterial wound dressings in medicine, etc.

A colloidal gold immunochromatographic method for rapid screening of imidacloprid residues in Chinese herbal medicines.

An imidacloprid colloidal gold immunochromatographic strip was developed in this work, and systematic analytical conditions were deeply investigated. The test strips were used for rapid screening of imidacloprid residues in Chinese herbal medicines. The performance of the colloidal gold test strips was investigated by using five selected Chinese herbal medicines (malt, Coix seed, lotus seed, dried ginger and honeysuckle).

The Relationship between Burnout and Sense of School Belonging among the Resident Physicians in the Standardization Training in China.

Background: As an important part in medical training in graduate school, 33-month medical residency training could be a stressful period inducing burnout (i.e. emotional exhaustion, depersonalization, and low personal accomplishment).

Acupuncture alleviates CUMS-induced depression-like behaviors of rats by regulating oxidative stress, neuroinflammation and ferroptosis.

Background: The treatment of depression with acupuncture has been documented. The mechanism behind acupuncture's curative and preventative effects is still unknown.

Methods: The current study examined the effects of acupuncture on depression-like behaviors in a rat model of chronic unpredictable mild stress (CUMS), while also exploring its potential mechanisms.

A multi-omics analysis strategy reveals the molecular mechanism of the inhibition of O157:H7 by anthocyanins from and its application.

Water pollution causes the propagation of pathogenic microorganisms, which poses a serious threat to human life. O157:H7, as a representative organism that can directly exhibit molecular response to stress, was selected as the indicator bacteria for the study. Tandem mass tag (TMT) quantitative proteomics and non-targeted metabolomics were used to study the response of O157:H7 to anthocyanin (AMA) treatment.

The effect of acupuncture on lateral habenular nucleus and intestinal microflora in depression model rats.

Background: Depression is a severe emotional condition that significantly affects the quality of life. Acupuncture exerts preventive effects on depression in rats with post-chronic unpredictable mild stress (CUMS). Methods The study involved chronic unpredictable mild stress (CUMS) depression model mice to administer acupuncture as a preventative measure to investigate the mechanism of acupuncture's antidepressant and observe the effect of acupuncture on impact via the Lateral Habenula (LHb) and Gut-Liver-Brain Axis.

Aqueous-Cellulose-Solvent-Derived Changes in Cellulose Nanocrystal Structure and Reinforcing Effects.

Cellulose nanocrystals as reinforcing agents have received considerable interest, and their dimension mainly depends on the original sources of cellulose. We intend to manually modulate the morphology of cellulose nanocrystals by treating them with cellulose solvents so that we can explore their reinforcing capacity. In this work, waste cotton fabric was processed in two aqueous solvents (a sulfuric acid aqueous solution and a NaOH/urea aqueous solution), and the regenerated cellulose was used to produce cellulose nanocrystals using acid hydrolysis.

The effects of acupuncture on depression by regulating BDNF-related balance via lateral habenular nucleus BDNF/TrkB/CREB signaling pathway in rats.

Depression is a major mental disease worldwide, causing dysfunction of Lateral Habenular (LHb). As a non-invasive alternative, acupuncture (AP) has been widely used to treat depression in clinic, yet few basic studies have been focused on the effects and mechanism of acupuncture on synaptic plasticity in LHb. Therefore, this study aimed to explore the potential mechanism of the antidepressant effect of acupuncture.

Acupuncture Alleviates CUMS-Induced Depression-Like Behaviors by Restoring Prefrontal Cortex Neuroplasticity.

Purpose: To explore the therapeutic efficiency of acupuncture and the related molecular mechanism of neural plasticity in depression.

Methods: Chronic unpredictable mild stress- (CUMS-) induced rats were established for the depression animal model. There were a total of four rat groups, including the control group, the CUMS group, the CUMS+acupuncture group, and the CUMS+fluoxetine group.

A clinical medicine level test at Jinan University School of Medicine reveals the importance of training medical students in clinical history-taking.

Backgrounds: Training in the basic interview skills of clinical history-taking has always been a significant component of medical education.

Purpose: This study was designed to identify the factors influence medical students' history-taking skills learning and develop a way to improve these skills.

Methods: We firstly analysed the academic performance of medical students at Jinan University School of Medicine in different disciplines of the Clinical Medicine Level Test (CMLT), to ensure the students have obtained comprehensive medical education prior to beginning their clinical internships.

Effects of α-casein on the excretion of blueberry anthocyanins via urine and feces: Analysis of their bioavailability.

Anthocyanins are bioactive compounds found in blueberries. However, their poor bioavailability restricts their functional activities in vivo, which is a challenging issue in the application of blueberry anthocyanins. Our current study utilized α-casein as a carrier and analyzed its influence on the excretion of blueberry anthocyanins in urine and feces in a rat model to reflect the enhanced bioavailability of blueberry anthocyanins by α-casein in vivo.

Acupuncture exerts preventive effects in rats of chronic unpredictable mild stress: The involvement of inflammation in amygdala and brain-spleen axis.

Background: Acupuncture has shown the preventive effects on depression in rats with chronic unpredictable mild stress (CUMS). However, the mechanisms of acupuncture for preventing depression still need to be explored. In the study, acupuncture was applied to a rat depression model of CUMS, high-mobility group box 1(HMGB1)/toll-like receptor 4 (TLR4) and brain-spleen axis were assessed.

Anthocyanins from Bound to Amylopectin Nanoparticles: Tissue Distribution and In Vivo Oxidative Damage Protection.

The in vivo applications of anthocyanins are limited by their instability. Nano-encapsulation using amylopectin nanoparticles (APNPs) stabilizes anthocyanins to deliver them to tissues to ameliorate their physiological functions. Herein, rats are fed four anthocyanins encapsulated with APNPs, and their subsequent distributions and bioactivity in nine tissues are revealed using UHPLC-MS.

Effect of Heat Treatment on Oxidation of Hazelnut Oil.

Thermal processing, a common processing method of vegetable oil in daily life, is accompanied by the formation of some harmful substances. This study determined the peroxide value, anisidine value, total peroxide value, polar compound content, fatty acid content, and core aldehyde content of hazelnut oil under different thermal processing conditions. The oxidation kinetics equation of fatty acid and temperature of hazelnut oil was established, and the correlation between the contents of fatty acid and core aldehyde and four oxidation indexes was analyzed.

Effects of mannoprotein on the stability and in vitro digestion of cyanidin-3-glucoside.

Although mannoprotein (MP) is known to increase the stability of anthocyanins, the MP-anthocyanin interactions and structural changes induced by the same remain underexplored. To bridge this gap, this work examined the complexation of cyanidin-3-glucoside (C3G) by MP and probed its effect on C3G properties. As a result, this complexation was shown to induce the static fluorescence quenching of MP and increase the thermal stability and antioxidant activity of C3G while decreasing its susceptibility to ascorbic acid, sucrose, and Fe-induced degradation and increasing its bioavailability during simulated in vitro digestion.

Effect of heat-treating methods on components, instrumental evaluation of color and taste, and antioxidant properties of sea buckthorn pulp flavonoids.

Sea buckthorn has strong physiological activities, which might be attributed to its flavonoid compounds. The heat treatment could speed up the transformation of the flavonoids, so it would affect the properties of the flavonoids. To explore the effect of the heat-treating methods on the sea buckthorn pulp flavonoids, the flavonoid compositions, color and taste properties, and antioxidant activity, prepared by three heating methods, were investigated.

Proteomic analyses revealed the antibacterial mechanism of isolated anthocyanins against O157: H7.

anthocyanins (AMAs), as a natural plant extract, can control pathogens and are attracting increasing attention. However, at the proteomic level, the antibacterial mechanism of AMAs against O157: H7 remains unclear. In this study, the tandem mass tag (TMT) quantitative proteomics was used to elucidate the potential antibacterial mechanisms of AMAs against O157: H7 cells.

Anthocyanin Extracts Improve Hepatic Structure and Function in High-Fat Diet-/Streptozotocin-Induced T2DM Mice.

Anthocyanins can prevent and ameliorate type 2 diabetes mellitus (T2DM), but its mechanism of action has not been fully established. IKK/NF-κB and JAK/Stat pathways have multiple effects, triggering T2DM. Liver abnormalities in individuals with T2DM are detrimental to glycemic control.

Electroacupuncture ameliorates peptic ulcer disease in association with gastroduodenal microbiota modulation in mice.

Peptic ulcer disease (PUD) is a common disease and frequently encountered in the clinic. Accumulating evidence suggests that PUD is associated with the gastrointestinal microbiota. Electroacupuncture (EA) is an improved version of acupuncture, which can improve the clinical effect by increasing the stimulation and delivering appropriate electrical pulses to needles.

Composition and antioxidant activity of anthocyanins from Aronia melanocarpa extracted using an ultrasonic-microwave-assisted natural deep eutectic solvent extraction method.

A time-saving, efficient, and environmentally friendly ultrasonic-microwave-assisted natural deep eutectic solvent (UMAE-NADES) extraction method was developed for the extraction of anthocyanins from Aronia melanocarpa. Eight different natural eutectic solvents were screened initially, and choline chloride-glycerol was selected as the extraction solvent. The extraction conditions were optimized using the response surface methodology, and the extraction rate of anthocyanins was higher than those achieved using the traditional ethanol method, natural deep eutectic solvent extraction method, and ultrasonic-microwave-assisted ethanol method.

Cyanidin-3-galactoside from ameliorates silica-induced pulmonary fibrosis by modulating the TGF-β/mTOR and NRF2/HO-1 pathways.

Cyanidin-3-galactoside (C3G), the most abundant anthocyanin in a, has many beneficial health effects, such as antioxidation. C3G was extracted from and applied (100, 200, and 400 mg/kg body weight) to 50-μl silica particles (SP) solution-exposed mice to research its antifibrotic properties using histological analysis, hydroxyproline assay, quantitative real-time polymerase chain reaction, and western blot analysis. The results showed that C3G treatment significantly ameliorated pulmonary fibrosis and cell infiltration into the lungs of mice.