Discovery, Synthesis, and Activity Evaluation of Novel Five-Membered Sulfur-Containing Heterocyclic Nucleosides as Potential Anticancer Agents In Vitro and In Vivo.

A series of novel five-membered sulfur-containing heterocyclic nucleoside derivatives were designed, synthesized, and evaluated for their anticancer activities in vitro and in vivo. The structure-activity relationship studies revealed that some of them showed obvious antitumor activities in several cancer cell lines. Among them, compound exhibited remarkable antiproliferative activity against HeLa cells and was more potent than cisplatin (IC = 2.

[Analysis of the principles of Tibetan medicine processing].

Tibetan medicine processing ensures the safety of clinical application of Tibetan medicine. It is of great significance to analyze the principles of Tibetan medicine processing in the development, inheritance, and innovation of Tibetan medicine. However, due to the late start of modern Tibetan medicine research and the disciplinary division, the current research on Tibetan medicine processing focuses on the exploration and collation of traditional techniques and the analysis of the processing mechanism of Tibetan medicine through chemical and pharmacological research, but its principles and traditional theories have been rarely reported.

Residue and distribution of drip irrigation and spray application of two diamide pesticides in corn and dietary risk assessment for different consumer groups.

Background: As the use of diamide insecticides on corn continues to increase, there is growing concern about their residue levels on corn and dietary risks to populations. In this study, the distribution, dispersion and transfer efficiency of two diamide insecticides (tetrachlorantraniliprole (TCAP) and cyantraniliprole (CNAP)) in different parts of corn and soil were investigated in a 1-year field trial in Guangzhou and Lanzhou using two different application methods - spray and drip irrigation, respectively - and the dietary risk of the insecticides to different consumer populations was assessed under the two application methods.

Results: The results showed that drip irrigation had a longer persistence period than spraying, and there was a hysteresis in the absorption distribution of the agent in different parts of corn, which was gradually transferred to the leaves after absorption from the roots.

Examination of acephate absorption, transport, and accumulation in maize after root irrigation for Spodoptera frugiperda control.

Since the invasion of the fall armyworm moth (Spodoptera frugiperda) in China in January 2019, damage to maize crops has gradually intensified, and chemical control has become the main control measure. This study aimed to examine methods of effective pest control while monitoring the environmental impact of pesticide use. The effectiveness of S.

Characterization of the complete chloroplast genome of the prickly blue poppy Hook. f. & Thomson (Ranunculales: Papaveraceae).

The prickly blue poppy ( Hook. f. & Thomson) is a traditional Tibetan medicinal herb with high values.

Characterization of the complete chloroplast genome of the Musk Larkspur (Ranunculales: Ranunculaceae).

Musk Larkspur () is a perennial herb of the family Ranunculace with medicinal values. In this study, the chloroplast (cp) genome of this herb was determined to be 153,926 bp long with an A + T-biased base composition, and comprises a pair of inverted repeat (IR) regions (26,559 bp), separated by a large single-copy (LSC) region (84,512 bp) and a small single-copy (SSC) region (16,296 bp). A total of 112 gene species were annotated with 19 of them being completely or partially duplicated.

Characterization of the complete chloroplast genome of the Tangut monkshood (Ranunculales: Ranunculaceae).

The Tangut monkshood () is a perennial herb with high medicinal values. Here, its chloroplast genome was assembled from Illumina sequencing reads. The circular genome is 157,114 bp long with an A + T-biased nucleotide composition, and comprises a pair of inverted repeat (IR) regions (26,255 bp), separated by a large single-copy (LSC) region (87,559 bp) and a small single-copy (SSC) region (17,045 bp).

Molecular Phylogeography and Evolutionary History of the Endemic Species (Papaveraceae) on the Tibetan Plateau Inferred From Chloroplast DNA and ITS Sequence Variation.

In response to past climatic changes, the species with different habits or adaptive traits likely have experienced very different evolutionary histories, especially for species that restricted to high mountain areas. In order to trace how Quaternary climatic oscillations affected range distributions and intraspecific divergence of such alpine plants on the Tibetan Plateau, here, we investigated maternally inherited chloroplast DNA (cpDNA) markers and biparentally inherited nuclear ribosomal internal transcribed spacer (ITS) DNA variations and aimed to explore the phylogeographic history of the endemic alpine species Hemsl. (Papaveraceae).

Characterization of the complete chloroplast genome of (Balsaminaceae: Impatiens), a rare and endemic Chinese flowering plant.

is a newly recorded rare and endemic flowering plant in China, which has been regarded as threatened due to its narrow distribution and human activity. In this study, its complete chloroplast genome was assembled from the whole genome Illumina sequencing data. The circular genome was 151,366 bp long, containing a large single copy (LSC) region of 82,245 bp and a small single copy (SSC) region of 17,705 bp, which were separated by a pair of 25,708 bp inverted repeat (IR) regions.

Amelioration of dry eye syndrome in db/db mice with diabetes mellitus by treatment with Tibetan Medicine Formula Jikan Mingmu Drops.

Ethnopharmacological Relevance: Jikan Mingmu Drops (JMD), a traditional Tibetan medicine containing six herbs, has been used to treat dry eye syndrome (DES) in individuals with diabetes mellitus.

Aim Of Study: However, the activity of JMD ameliorates DES with diabetes mellitus has not been previously examined. The aim of the study is to investigate the molecular mechanism of JMD on db/db mice.

The expression of AEG-1 and Cyclin D1 in human bladder urothelial carcinoma and their clinicopathological significance.

Objective: Astrocyte elevated gene-1 (AEG-1) and Cyclin D1 is associated with tumorigenesis and progression. The aim of this study is to investigate the expression of AEG-1 and Cyclin D1 in human bladder urothelial carcinoma (BUC) and explore their clinical and pathological significance.

Methods: The expression of AEG-1 and Cyclin D1 protein were detected in 85 cases of human BUC and 16 cases of tumor-adjacent tissues by the immunohistochemical method.

Effect of Matrine on HPAC cell migration by down-regulating the expression of MT1-MMP via Wnt signaling.

Aim: This study sought to explore the exact mechanism of Matrine inhibited migration and invasion of human pancreatic cancer cells.

Methods: HPAC or Capan-1 cells were cultured in completed RPMI-1640 medium, contained with 50 μg/ml Matrine or 0.05 μg/ml docetaxel, respectively.

[Exploring application of data mining technology in researching composition rules of Tibetan medical formulas].

There are thousands of medicinal formulas in the ancient Tibetan medical texts. Researching the composition rules of Tibetan medical formulas is a very important step in the study and practice of Tibetan medicine. In order to explore the composition rules of Tibetan medical formulas this article draws on the research methods utilized in related fields of traditional Chinese medicine adapted to the unique characteristics of Tibetan medicine.