Double Confinement Design to Access Highly Stable Intermetallic Nanoparticles for Fuel Cells.

Maintaining the stability of low Pt catalysts during prolonged operation of proton exchange membrane fuel cells (PEMFCs) remains a substantial challenge. Here, a double confinement design is presented to significantly improve the stability of intermetallic nanoparticles while maintaining their high catalytic activity toward PEMFCs. First, a carbon shell is coated on the surface of nanoparticles to form carbon confinement.

Quercetin improves airway remodeling in COPD rats by suppressing phenotypic switch of ASMCs via inhibiting the Wnt5a/β-catenin pathway.

Background And Purpose: Airway remodeling in chronic obstructive pulmonary disease (COPD) is a contributor to airflow limitation, promotes disease progression, and affects disease outcome and prognosis. Quercetin has been identified as a potential therapeutic agent for COPD. Currently, there is insufficient research providing direct evidence to support this hypothesis.

Efficacy of a Modified Bilhaut-Cloquet Procedure Using a Neurovascular Island Flap for Treatment of Radially Deviated Thumb Polydactyly With Hypoplasia.

Purpose: Baek's modified Bilhaut-Cloquet procedure is indicated for patients with symmetric bifid thumbs in Wassel type II or III polydactyly. The radially deviated type of thumb polydactyly with asymmetric bifid thumbs was previously contraindicated for this procedure. The objective of the study was to describe the results of our modified Bilhaut-Cloquet procedure using a neurovascular island flap of the radial duplicate for radially deviated type of thumb polydactyly with hypoplasia.

Danshensu enhances autophagy and reduces inflammation by downregulating TNF-α to inhibit the NF-κB signaling pathway in ischemic flaps.

Background: The significant distal necrosis of the random-pattern skin flaps greatly restricts their clinical applications in flap transplantation. Previous studies have demonstrated the potential of danshensu (DSS) to alleviate ischemic tissue injury. However, no research to date has confirmed whether DSS can improve the survival of ischemic flaps.

Programmable Self-Assembly from Two-Dimensional Nanosheets to Spiral, Twisted and Branched Nanostructures.

Self-assembly of nanomaterials into hierarchical structure is of great interest to fabricate functional materials. However, programmable design of the assembled structures remains a great challenge. Herein, we reported a programmable self-assembly strategy to customize the assembled structure.

PKM2-Driven Lactate Overproduction Triggers Endothelial-To-Mesenchymal Transition in Ischemic Flap via Mediating TWIST1 Lactylation.

The accumulation of lactate is a rising risk factor for patients after flap transplantation. Endothelial-to-mesenchymal transition (EndoMT) plays a critical role in skin fibrosis. Nevertheless, whether lactate overproduction directly contributes to flap necrosis and its mechanism remain unknown.

Enhancing the Electrocatalytic Oxidation of 5-Hydroxymethylfurfural Through Cascade Structure Tuning for Highly Stable Biomass Upgrading.

Electrocatalytic 5-hydroxymethylfurfural oxidation reaction (HMFOR) provides a promising strategy to convert biomass derivative to high-value-added chemicals. Herein, a cascade strategy is proposed to construct Pd-NiCoO electrocatalyst by Pd loading on Ni-doped CoO and for highly active and stable synergistic HMF oxidation. An elevated current density of 800 mA cm can be achieved at 1.

Local CO Generator Enabled by a CO-Producing Core for Kinetically Enhancing Electrochemical CO Reduction to Multicarbon Products.

CO plays a crucial role as an intermediate in electrochemical CO conversion to generate multicarbon (C) products. However, optimizing the coverage of the CO intermediate (*CO) to improve the selectivity of C products remains a great challenge. Here, we designed a hierarchically structured double hollow spherical nanoreactor featuring atomically dispersed nickel (Ni) atoms as the core and copper (Cu) nanoparticles as the shell, which can greatly improve the catalytic activity and selectivity for C compounds.

Dihydrocapsaicin suppresses the STING-mediated accumulation of ROS and NLRP3 inflammasome and alleviates apoptosis after ischemia-reperfusion injury of perforator skin flap.

Avascular necrosis frequently occurs as a complication following surgery involving the distal perforator flap. Dihydrocapsaicin (DHC) can protect tissue from ischemia-reperfusion (I/R) injury, but its specific role in multizone perforator flaps remains unclear. In this study, the prospective target of DHC in the context of I/R injury was predicted using network pharmacology analysis.

Alleviating OH Blockage on the Catalyst Surface by the Puncture Effect of Single-Atom Sites to Boost Alkaline Water Electrolysis.

Nonprecious transition metal catalysts have emerged as the preferred choice for industrial alkaline water electrolysis due to their cost-effectiveness. However, their overstrong binding energy to adsorbed OH often results in the blockage of active sites, particularly in the cathodic hydrogen evolution reaction. Herein, we found that single-atom sites exhibit a puncture effect to effectively alleviate OH blockades, thereby significantly enhancing the alkaline hydrogen evolution reaction (HER) performance.

Axial Dual Atomic Sites Confined by Layer Stacking for Electroreduction of CO to Tunable Syngas.

Arranging atoms in an orderly manner at the atomic scale to create stable polyatomic structures is a very challenging task. In this study, we have developed three-dimensional confinement areas on the two-dimensional surface by creating regional defects. These areas are composed of vertically stacked graphene layers, where Ni and Fe atoms are anchored concentrically to form axial dual atomic sites in high yield.

Establishment and Validation of a Pathologic Upgrade Prediction Nomogram Model for Gastric Low-Grade Intraepithelial Neoplasia Patients After the Eradication of .

Background: As yet, there is no unified method of treatment for the evaluation and management of gastric low-grade intraepithelial neoplasia (LGIN) worldwide.

Methods: Patients with gastric LGIN who had been treated with eradication were gathered retrospectively. Based on several relevant characteristics described and analyzed by LASSO regression analysis and multivariable logistic regression, a prediction nomogram model was established.

Precise Regulation of Iron Spin States in Single FeN Sites for Efficient Peroxidase-Mimicking Catalysis.

The catalytic activity and selectivity of single-atom sites catalysts is strongly dependent on the supports structure and central metal coordination environment. However, the further optimization of electronic configuration to improve the catalytic performance is usually hampered by the strong coordination effect between the support and metal atoms. Herein, it is discovered that enzyme-mimicking catalytic performance can be enhanced at the fixed coordination single-atom Fe sites by regulating the Fe spin states.