Cord serum metabolomic profiling associated with in utero exposure to per- and polyfluoroalkyl substances and birthweight discordance in twins: Findings from Wuhan Twin Birth Cohort.

Emerging evidence links per- and polyfluoroalkyl substances (PFAS) exposure and metabolic disruptions to fetal growth retardation. However, earlier studies on singletons couldn't fully account for genetic factors. Therefore, we used a co-twin control study design to identify cord metabolomic signatures of PFAS exposure and assess its mediating role in twin birthweight discordance.