Reversibly Modulating the Selectivity of Carbon Dioxide Reduction via Ligand-Driven Spin Crossover.

Selectivity is an essential aspect in catalysis. At present, the improvement of the selectivity for complex reactions with multiple pathways/products, for example the carbon dioxide reduction reaction (CORR), can usually be achieved for only one pathway/product. It is still a challenge to reversibly modulate the selectivity between two reaction pathways or products of the CORR by one catalyst.

The effectiveness of Tai Chi for patients with mild cognitive impairment: a systematic review and meta-analysis.

Objective: To explore the effectiveness of Tai Chi on cognitive function in patients with mild cognitive impairment (MCI).

Methods: According to the PRISMA guidelines, randomized controlled trial (RCT) literature on the efficacy of Tai Chi on MCI patients was searched in China National Knowledge Network (CNKI), China Biomedical Literature Database (CBM), Wanfang Data, China Scientific Journal Database (VIP), PubMed, Embase, Duxiu Database, Web of Science and Cochrane Library from their inception to April 2024. The risk of bias in each study was appraised using the Cochrane risk-of-bias tool using Revman 5.

[Clinical and genetic analysis of a case with 2p23.2p22.1 duplication].

Objective: To report on the phenotype of an adult patient with 2p23.2p22.1 duplication and explore its genotype-phenotype correlation.

Design of a Self-Sufficient Whole-Cell Cascade for the Production of ()-Citronellal from Geraniol.

()-Citronellal is a key chiral precursor of high-value chemicals, such as the best-selling flavor compound (-)-menthol; however, the conventional synthesis suffers from low yield and unsatisfactory enantioselectivity. In this study, we developed a highly atom-efficient hydrogen-borrowing cascade for the synthesis of ()-citronellal from geraniol using alcohol dehydrogenase from K12 (AdhP) and ene-reductase from YJM1341 (OYE2p). The key rate-limiting enzyme, AdhP, was subjected to structure-guided semirational engineering, and the triple mutant AdhP (M3) was obtained that demonstrated a 1.

Mechanistic insight on nanomaterial-induced reactive oxygen species formation.

Reactive oxygen species (ROS) are closely related to cell death, proliferation and inflammation. However, excessive ROS levels may exceed the cellular oxidative capacity and cause irreversible damage. Organisms are often inadvertently exposed to nanomaterials (NMs).

Vina-GPU 2.1: Towards Further Optimizing Docking Speed and Precision of AutoDock Vina and Its Derivatives.

AutoDock Vina and its derivatives have established themselves as a prevailing pipeline for virtual screening in contemporary drug discovery. Our Vina-GPU method leverages the parallel computing power of GPUs to accelerate AutoDock Vina, and Vina-GPU 2.0 further enhances the speed of AutoDock Vina and its derivatives.

High-Performance Wearable Joule Heater Derived from Sea-Island Microfiber Nonwoven Fabric.

A three-dimensional (3D) hierarchical microfiber bundle-based scaffold integrated with silver nanowires (AgNWs) and porous polyurethane (PU) was designed for the Joule heater via a facile dip-coating method. The interconnected micrometer-sized voids and unique hierarchical structure benefit uniform AgNWs anchored and the formation of a high-efficiency 3D conductive network. As expected, this composite exhibits a superior electrical conductivity of 1586.

-Y262C mutation causes abnormal zona pellucida formation and female infertility in humans.

Defective oocyte maturation is a common cause of female infertility. The loss of the zona pellucida (ZP) represents a specific condition of impaired oocyte maturation. The extracellular matrix known as the ZP envelops mammalian oocytes and preimplantation embryos, exerting significant influence on oogenesis, fertilization, and embryo implantation.

Efficacy of Baduanjin for obesity and overweight: a systematic review and meta-analysis.

Background: According to data from the World Health Organization (WHO), there is a significant public health issue regarding the increasing number of individuals affected by obesity and overweight on an annual basis. Therefore, it is imperative to urgently identify interventions that can effectively control and improve this condition. Baduanjin, as a medium-intensity exercise, appears a suitable approach for weight reduction among individuals with obesity.

Cardiovascular toxic effects of nanoparticles and corresponding molecular mechanisms.

Rapid advancements in nanotechnology have been integrated into various disciplines, leading to an increased prevalence of nanoparticle exposure. The widespread utilization of nanomaterials and heightened levels of particulate pollution have prompted government departments to intensify their focus on assessing the safety of nanoparticles (NPs). The cardiovascular system, crucial for maintaining human health, has emerged as vulnerable to damage from nanoparticle exposure.

Nontarget Discovery of Per- and Polyfluoroalkyl Sulfonyl Halides in Soils by Integration of Derivatization and Specific Fragment-Based Liquid Chromatography-High Resolution Mass Spectrometry Screening.

Though long recognized as synthetic precursors to other poly- and perfluoroalkyl substances (PFASs), most poly- and perfluoroalkyl sulfonyl halides (PASXs) cannot be directly measured and have generally received minimal attention. Inspired by the redox reaction between sulfonyl halide groups and -toluenethiol in organic chemistry, we developed a novel nontarget analysis strategy for PASXs by intergrating derivatization and specific fragment-based liquid chromatography-high resolution mass spectrometry screening for / 82.961 [SOF] and / 95.

Developing Salt-Rejecting Evaporators for Solar Desalination: A Critical Review.

Solar desalination, a green, low-cost, and sustainable technology, offers a promising way to get clean water from seawater without relying on electricity and complex infrastructures. However, the main challenge faced in solar desalination is salt accumulation, either on the surface of or inside the solar evaporator, which can impair solar-to-vapor efficiency and even lead to the failure of the evaporator itself. While many ideas have been tried to address this ″salt accumulation″, scientists have not had a clear system for understanding what works best for the enhancement of salt-rejecting ability.

Management of Nontraumatic Spontaneous Renal Hemorrhage (Wünderlich Syndrome) through Robotic-Assisted Laparoscopic Nephrectomy: A Case Series.

BACKGROUND Wünderlich syndrome (WS) is a rare diagnosis of nontraumatic spontaneous renal hemorrhage into the subcapsular, perirenal, or pararenal spaces. Prompt and effective intervention is necessary for an accurate pathological diagnosis and preservation of life. In the current literature, open surgery is the primary option when conservative treatment fails, but there can be serious trauma and corresponding consequences.

[Genetic origin analysis of regions of homozygosity in three cases].

Objective: To explore the genetic characteristics of three fetuses with regions of homozygosity (ROH).

Methods: Three fetuses with ROH diagnosed at Nanjing Drum Tower Hospital on December 2, 2020, March 19, 2021, and May 27, 2022, respectively were selected as the study subjects. Clinical data of the fetuses were collected.

The effects of different types of Tai Chi exercises on preventing falls in older adults: a systematic review and network meta-analysis.

Objectives: Few studies comparing the effects of different types of Tai Chi exercises on preventing falls in older adults. We compared the effects for finding an optimal intervention.

Methods: We searched 12 databases, including PubMed, EMBASE, Cochrane Library, Chinese National Knowledge Infrastructure (CNKI) and so on, from their inception to January 13, 2023.

First-Principles Insights into Tungsten Semicarbide-Based Single-Atom Catalysts: Single-Atom Migration and Mechanisms in Oxygen Reduction.

Understanding the structural evolution of single-atom catalysts (SACs) in catalytic reactions is crucial for unraveling their catalytic mechanisms. In this study, we utilize density functional theory calculations to delve into the active phase evolution and the oxygen reduction reaction (ORR) mechanism of tungsten semicarbide-based transition metal SACs (TM/WC). The stable crystal phases and optimal surface exposures of WC are identified by using atomistic thermodynamics simulations.

Micro(nano)-plastics exposure induced programmed cell death and corresponding influence factors.

Plastic products have played an indispensable role in our daily lives for several decades, primarily due to their cost-effectiveness and unmatched convenience. Nevertheless, recent developments in nanotechnology have propelled our attention toward a distinct category of plastic fine particulates known as micro(nano)-plastics (MPs/NPs). The investigation of the cytotoxic effects of MPs/NPs has emerged as a central and burgeoning area of research in environmental toxicology and cell biology.

Lightweight and Real-Time Infrared Image Processor Based on FPGA.

This paper presents an FPGA-based lightweight and real-time infrared image processor based on a series of hardware-oriented lightweight algorithms. The two-point correction algorithm based on blackbody radiation is introduced to calibrate the non-uniformity of the sensor. With precomputed gain and offset matrices, the design can achieve real-time non-uniformity correction with a resolution of 640×480.

Developmental Shifts in the Microbiome of a Cosmopolitan Pest: Unraveling the Role of and Dominant Bacteria.

bacteria (phylum Proteobacteria) are ubiquitous intracellular parasites of diverse invertebrates. In insects, coevolution has forged mutualistic associations with species, influencing reproduction, immunity, development, pathogen resistance, and overall fitness. However, the impact of on other microbial associates within the insect microbiome, which are crucial for host fitness, remains less explored.

Natural Disinfection-like Process Unveiled in Soil Microenvironments by Enzyme-Catalyzed Chlorination.

Substantial natural chlorination processes are a growing concern in diverse terrestrial ecosystems, occurring through abiotic redox reactions or biological enzymatic reactions. Among these, exoenzymatically mediated chlorination is suggested to be an important pathway for producing organochlorines and converting chloride ions (Cl) to reactive chlorine species (RCS) in the presence of reactive oxygen species like hydrogen peroxide (HO). However, the role of natural enzymatic chlorination in antibacterial activity occurring in soil microenvironments remains unexplored.