Designing small organic molecular NIR-II fluorophores by ring strain modulation.

Developing small molecular organic fluorophores in the second near-infrared window (NIR-II, 1000-1700 nm) with excellent photophysical properties is an ongoing pursuit for bioimaging and biosensing. Herein, we report a strategy to modulate the optical properties of xanthene-based fluorophores by manipulating their ring strain through fine-tuning the ring size, which strongly influences the rigidity and planarity of the conjugated structure, thereby impacting their optical characteristics. Additionally, the ring strain imparts varying responsiveness to the fluorophores by affecting the p values through spirocyclization.

Neural dynamics of deception: insights from fMRI studies of brain states.

Unlabelled: Deception is a complex behavior that requires greater cognitive effort than truth-telling, with brain states dynamically adapting to external stimuli and cognitive demands. Investigating these brain states provides valuable insights into the brain's temporal and spatial dynamics. In this study, we designed an experiment paradigm to efficiently simulate lying and constructed a temporal network of brain states.

Cancer-associated fungi: An emerging powerful player in cancer immunotherapy.

The role of the human microbiome in cancer has been extensively studied, focusing mainly on bacteria-host interactions and their impact on tumor development and treatment response. However, fungi, an immune-active component of the human microbiome, have received less attention regarding their roles in cancer. Recent studies have identified the widespread and specific colonization and distribution of fungi in multiple sites in patients across various cancer types.

Reinventing the High-rate Energy Storage of Hard Carbon: the Order-degree Governs the Trade-off of Desolvation-Solid Electrolyte Interphase at Interfaces.

In alkali metal-ion battery systems, the electrolyte enables being decomposed on the electrode surface to form a solid electrolyte interphase (SEI) film. In principle, a thin, uniform SEI film facilitates the enhancement of the performance of the cell. Herein, we successfully distinguish the effects of desolvation behavior and SEI process on the kinetic behavior of hard carbon (HC) electrodes by adopting the strategy of switching the electrolyte interface model to modulate the properties of SEI film.

In Vivo Time-Resolved Single-Cell RNA-Seq Reveals Chemotherapy-Induced Transcriptional Dynamics in Tumor Infiltrating Lymphocytes.

Single-cell RNA sequencing (scRNA-seq) using metabolic RNA labeling enables detailed analysis of dynamic gene expression within single cells. However, most studies are limited to in vitro settings, restricting the exploration of in vivo transcriptomic dynamics. To address this, we developed scDyna-seq, a time-resolved scRNA-seq method for in vivo applications using 4-thiouridine (4sU) labeling.

Single-atom Co-N-C nanozymes with excellent oxidase-like activity for colorimetric detection of l-cysteine.

l-Cysteine (l-Cys) is a significant biomarker for various diseases, including liver disease, skin disorders, and Parkinson's disease, making its detection crucial for diagnostic purposes. In this study, we present a novel colorimetric sensing platform for l-Cys detection. Using ZIF-8 as a precursor, a cobalt-based single-atom catalyst (Co-N-C) was synthesized through pyrolysis, adsorption, and activation processes.

Non-orthogonal multiple access scheme based on color-coded four-dimensional constellation pairing mapping.

This paper proposes a short-range optical access method based on four-dimensional non-orthogonal multiple access (4D-NOMA), utilizing 4D constellation pairing mapping and two-dimensional inverse discrete Fresnel transform (2D-IDFnT) technology, achieving high compatibility with OFDM systems. An innovative color-coded 4D constellation pair mapping scheme was designed, introducing two types of four-dimensional spatial structures with 32 constellation points. By extending the three-dimensional constellation to four dimensions through color coding, the constellation figure of merit (CFM) increased by 22.

Populations of the Invasive Mussel in China Showed Lower Genetic Diversity in Autumn than in Spring.

Native to tropical America, the charru mussel, , has been spreading rapidly in the West Pacific Ocean, including the South China Sea. In order to study the adaptive evolution of and examine the present status of invasion in China, the mitochondrial gene fragment was employed to analyze the genetic variations of seven populations sampled in both spring and autumn 2023. Results showed that all the populations had high haplotype diversity (>0.

High-security physical layer encryption scheme for dual-mode index modulation-aided OFDM in magnetic induction communication.

A high security physical layer encryption scheme for dual-mode orthogonal frequency division multiplexing with index modulation (DM-OFDM-IM) in magnetic induction communication is proposed. The scheme utilizes DM-OFDM-IM, where subcarriers within each subblock are divided into two groups, each modulated by distinct signal constellations. DM-OFDM-IM leverages the sequential information from the modulated constellation to transmit extra information, leading to a substantial enhancement in spectral efficiency.

Efficient Bifunctional Electrocatalysts for Oxygen Evolution/Reduction Reactions in Two-Dimensional Metal-Organic Frameworks by a Constant Potential Method.

The evolution of bifunctional catalysts for the oxygen reduction reaction (ORR) and oxygen evolution reaction (OER) catalysts that are highly active, stable, and conductive is crucial for advancing metal-air batteries and fuel cells. We have here thoroughly explored the OER and ORR performance for a category of two-dimensional (2D) metal-organic frameworks (MOFs) called TM(HADQ), and Rh(HADQ) exhibits a promising bifunctional OER/ORR activity, with an overpotential of 0.31 V for both OER and ORR.

Evaluation of Multispecific Drugs Based on Patient-Derived Immunocompetent Tumor Organoids.

The evolution of antitumor drug development has transitioned from single-agent chemotherapy to targeted therapy, immunotherapy, and more recently, multispecific drugs. These innovative drugs target multiple cellular or molecular pathways simultaneously, offering a more comprehensive anticancer approach and addressing some of the limitations inherent in traditional monotherapies. However, preclinical assessment of multispecific drugs remains challenging, as conventional tumor models often lack the necessary complexity to accurately reflect the interactions between various cell types and targets.

Intratumoral Injection of Engineered Induces Antitumor Immunity and Inhibits Tumor Growth.

Conventional type 1 dendritic cells are essential for antigen presentation and successful initiation of antitumor CD8 T cells. However, their abundance and function within tumors tend to be limited. , a fast-growing, nonpathogenic mycobacterium, proves to be easily modified with synthetic biology.

Palmitoylation-mediated NLRP3 inflammasome activation in teleosts highlights evolutionary divergence in immune regulation.

NLRP3 inflammasome activation is pivotal for cytokine secretion and pyroptosis in response to diverse stimuli, playing a crucial role in innate immunity. While extensively studied in mammals, the regulatory mechanisms governing NLRP3 activation in non-mammalian vertebrates remain largely unexplored. Teleosts, as basal vertebrates, represent an ideal model for exploring the evolutionary trajectory of inflammasome regulation.

Highly secure OFDM scheme based on multi-level masking and performance-enhanced key accompanying transmission.

In this Letter, we propose a highly secure OFDM scheme based on multi-level masking and performance-enhanced key-accompanying transmission. Our scheme exploits a four-dimensional hyperchaotic model and uses subcarriers and symbols to scramble the signal, thereby achieving chaotic encryption and enhancing system security. The dual-mode index technique is employed to conceal the key within the encrypted signal, enabling cooperative transmission of both the key and the signal.

Roundabout Mechanism of Ion-Molecule Nucleophilic Substitution Reactions.

Roundabout (RA) is an important indirect mechanism for gas-phase X + CHY → XCH + Y S2 reactions at a high collision energy. It refers to the rotation of the CH-group by half or multiple circles upon the collision of incoming nucleophiles before substitution takes place. The RA mechanism was first discovered in the Cl + CHI S2 reaction to explain the energy transfer observed in crossed molecular beam imaging experiments in 2008.

Single-Cell Multiomics Identifies Glycan Epitope LacNAc as a Potential Cell-Surface Effector Marker of Peripheral T Cells in Bladder Cancer Patients.

Cancer is a systemic disease continuously monitored and responded to by the human global immune system. Peripheral blood immune cells, integral to this surveillance, exhibit variable phenotypes during tumor progression. Glycosylation, as one of the most prevalent and significant post-translational modifications of proteins, plays a crucial role in immune system recognition and response.

Polar coded SCMA-OCDM based on chaotic scrambled SLM.

In this work, the polar coded sparse code multiple access (SCMA) scheme based on chaotic scrambled selective mapping (CS_SLM) is proposed for future passive optical networks (PONs). The original bits are coded by polar and mapped into constellation symbols by sparse code. Then orthogonal chirp division multiplexing (OCDM) modulation is adopted which has better anti-interference ability than orthogonal frequency division multiplexing (OFDM).

Revealing the Structural Architecture of Anions Confining MoCT MXene Layers for Robust Li Storage.

Controllable cation preintercalation enables enhancing the electrochemical activity and kinetics of MXenes. However, the electrostatic repulsion between cations and electrolyte ions induces deteriorative electrolyte ion transport kinetics. Herein, by shifting perceptions from the cation to anion strategies, we successfully preintercalate Cl, SO, and PO anions into MoCT MXene via the utilization of diverse etching agents.

Simplified bit-class probabilistic shaping strategy based on PDM systems.

This study aims to present a simplified bit-class probabilistic shaping (PS) strategy based on power domain multiplexing (PDM) systems. In this scheme, we employ bit-weighted distribution matching (BWDM) to achieve PS. By ingeniously applying the process of signal superposition, the low-complexity bit-class PS scheme requires encoding of only a small number of bits in the low-power two quadrature phase-shift keying (QPSK) signal, enhancing the quality of the transmitted signal with simple operations.

Enhancing secure transmission of ultra-high order QAM via delta-sigma modulation integrated with radial basis function neural network enhanced chaos.

This paper proposes and experimentally demonstrates an ultra-high order signal security enhancement method based on delta-sigma modulation (DSM). We employ a radial basis function neural network (RBFnn) to enhance Henon chaos, effectively avoiding the degradation of chaotic dynamics, and increasing the key space from 10 to 10. In the experimental demonstration, we achieved high-security transmission of 16384QAM over 25 km in an intensity-modulated direct detection (IMDD) system based on DSM.

Enhanced 4D-OFDM optical communication systems with color-coded constellations and probability constellation shaping.

The present work introduces a four-dimensional probability constellation mapping OFDM optical transmission system based on a two-dimensional inverse fast Fourier transform (2D-IFFT). A four-dimensional constellation structure employing color coding is designed, amalgamating geometric shaping with probability shaping to enhance the constellation figure of merit (CFM). Successful transmission of OFDM signals at 51.