Publications by authors named "Xiangyu Ni"
Exosome-derived proteins in gastric cancer progression, drug resistance, and immune response.
Cell Mol Biol Lett
December 2024
Gastric cancer (GC) represents a prevalent malignancy globally, often diagnosed at advanced stages owing to subtle early symptoms, resulting in a poor prognosis. Exosomes are extracellular nano-sized vesicles and are secreted by various cells. Mounting evidence indicates that exosomes contain a wide range of molecules, such as DNA, RNA, lipids, and proteins, and play crucial roles in multiple cancers including GC.
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- The review discusses how intermittent fasting (IF) and fasting-mimicking diets (FMD) can slow down tumor growth by affecting key cellular signaling pathways, such as AKT, Nrf2, and AMPK.
- IF and FMD may boost the immune response to tumors by influencing various immune cells, including T cells and macrophages, potentially improving cancer treatment outcomes.
- Clinical trials suggest that IF and FMD are safe and can enhance the effectiveness of traditional cancer therapies while reducing side effects, leading to better overall quality of life for patients.
Background: Dysregulation of zinc homeostasis is widely recognized as a hallmark feature of prostate cancer (PCa) based on the compelling clinical and experimental evidence. Nevertheless, the implications of zinc dyshomeostasis in PCa remains largely unexplored.
Methods: In this research, the zinc homeostasis pattern subtype (ZHPS) was constructed according to the profile of zinc homeostasis genes.
Aerobic glycolysis has been shown to play a key role in tumor cell proliferation and metastasis. However, how it is directly regulated is largely unknown. Here, we found that HES1 expression was significantly higher in CRC tissues than that in adjacent normal tissues.
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