hsa_circ_0000417 downregulation suppresses androgen receptor expression and apoptotic signals in human foreskin fibroblasts via sponging miR-6756-5p.

Background: Dysregulated apoptosis of penile mesenchymal cells during male urethragenesis has been previously demonstrated to underly hypospadiac urethral closure failure, and androgen receptor (AR) has been shown to play a central role in regulating penile mesenchyme cell proliferation and survival. However, the regulatory mechanisms upstream and downstream of AR remain poorly understood. Our clinical data and bioinformatics analysis previously indicated that hsa_circ_0000417, a circRNA significantly downregulated in hypospadias preputial specimens, may act as a ceRNA for AR via sequestering hsa_miR-6756-5p, and that the biological functions of hsa_circ_0000417 may significantly involve the PI3K/AKT pathway.

The effect of staged TIP urethroplasty on proximal hypospadias with severe chordee.

Background: Proximal hypospadias with severe chordee is still a formidable challenge for most pediatric urologists, and the treatment approach remains controversial. Here, we describe a modified two-stage technique to repair proximal hypospadias with severe chordee.

Methods: We retrospectively identified 53 children referred for proximal hypospadias with severe chordee from July 2016 to July 2019, who underwent a two-stage urethroplasty.

MiR-135a-5p and Mst1 regulate MPP + -1 induced apoptosis and autophagy in Parkinson's disease model in vitro.

The mammalian Ste20-like kinases 1 (Mst1) is essential for regulating cell proliferation, differentiation, apoptosis, and autophagy. However, the molecular mechanisms of Mst1 in neuronal cell death remains incompletely understood. Here, we showed that Mst1 is up-regulated in Parkinson's disease (PD) model induced by MPP.

The involvement of hsa_circ_0000417 in the development of hypospadias by regulating AR.

Background: Congenital hypospadias is a common congenital malformation of the urinary system in male children. However, the role of circRNA in congenital hypospadias remains unknown.

Methods: Differentially expressed circRNAs and mRNAs were identified by RNA sequencing.