[Current status of oral health literacy and its influencing factors among adult orthodontic patients].

Purpose: To investigate the current status of oral health literacy among adult orthodontic patients and analyze its influencing factors.

Methods: Totally 163 adult orthodontic patients were recruited by convenience sampling method from November 2021 to February 2022 at the Department of Oral and Craniomaxillofacial Surgery, Center of Craniofacial Orthodontics in Shanghai Ninth People's Hospital. General information questionnaire, Chinese version of Health Literacy in Dentistry (HeLD-14), Chinese version of Self-Efficacy Scale for Self-care (SESS) and Social Support Rating Scale (SSRS) were applied.

Vertical distribution rules and factors influencing phytoplankton in front of a drinking water reservoir outlet.

The phenomenon of algal blooms caused by the excessive proliferation of phytoplankton in drinking water reservoirs is becoming increasingly frequent, seriously endangering water quality, ecosystems, water safety, and people's health. Thus, there is urgent need to conduct research on the distribution rules and factors influencing phytoplankton in drinking water reservoirs. Given that the outflows from reservoirs usually come from the middle and lower layers of the water column and the current studies on phytoplankton in drinking water reservoirs are usually carried out on the surface, an 8-month monitoring of vertical phytoplankton and the corresponding influencing factors in front of the outlet in a drinking water reservoir was conducted.

Melatonin Engineering M2 Macrophage-Derived Exosomes Mediate Endoplasmic Reticulum Stress and Immune Reprogramming for Periodontitis Therapy.

Periodontitis is a chronic infectious disease caused by bacterial irritation. As an essential component of the host immunity, macrophages are highly plastic and play a crucial role in inflammatory response. An appropriate and timely transition from proinflammatory (M1) to anti-inflammatory (M2) macrophages is indispensable for treating periodontitis.

Molecular insight of p53/Sp1/MUC5AC axis in the tumorigenesis and progression of lung adenocarcinoma.

The aberrant expression of secretory mucin MUC5AC has been documented during the tumourigenesis and progression of various cancers. However, little is currently known on the function of MUC5AC in lung adenocarcinoma. The present study focused on the tumour-promoting role of MUC5AC and its regulatory mechanisms in lung adenocarcinoma.

Combined Surgical-Orthodontic Treatment of Patients With Severe Parry-Romberg Syndrome.

Parry-Romberg syndrome (PRS) refers to a relatively rare dysfunction disease that is characterized by chronic progressive maxillofacial atrophy, especially one side of facial skin, subcutaneous tissue, muscle, and bone. According to the atrophy degree of skin, subcutaneous tissue, and skeleton in the area innervated by the trigeminal nerve, PRS can be classified into mild, moderate, and severe. In general, cases with different severity have specific treatment regimens.

[Analysis of information needs of patients with dentofacial deformities at different stages of treatment].

Purpose: To investigate the treatment experience and information needs of patients with dentofacial deformities in the process of surgical program design, surgical treatment and postoperative rehabilitation.

Methods: Thirty-six patients with dentofacial deformities at different treatment stages from March to July 2019 were selected for semi-structured interview. Colaizzi content analysis method and QSR NVivo 12.

Rapid BMI Increases and Persistent Obesity in Small-for-Gestational-Age Infants.

In order to compensate for the early intrauterine growth restriction, small-for-gestational age (SGA) infants have "catch-up growth" after birth. Increased caloric intake has been suggested for SGA infants conventionally. It is important to determine if the early growth rate of body mass index (BMI) is associated with risk of persistent obesity later in life.

Eating Habits and Their Association with Weight Status in Chinese School-Age Children: A Cross-Sectional Study.

Background: Poor eating habits increase children's risk of chronic diseases such as overweight and obesity, adult diabetes, and cardiovascular and cerebrovascular diseases. Therefore, this study aimed to examine the eating habits of school-age children and their impact on children's body mass index.

Methods: Multistage cluster sampling was used to sample 2224 students in grades 4 to 6 from 16 primary schools in Changsha.

[Qualitative study on the decision-making of orthognathic surgery in adult patients with malocclusion].

Purpose: The main purpose of this study was to explore the experience associated with patient's decision to have or not have orthognathic treatment.

Methods: Phenomenological methodology was used in this study. Ten patients were collected from January 2018 to March 2018, who were consulted in the Department of Oral and Craniomaxillofacial Surgery, Center of Craniofacial Orthodontics in Shanghai Ninth People's Hospital.

Influencing factors of the neurodevelopment of high-risk infants.

Background: High-risk infants refer to newborns exposed to high-risk factors in the prenatal, natal or postnatal period. High-risk infants are at high risk of developmental retardation, and early identification of developmental abnormalities plays a vital role in improving high-risk infants' quality of life.

Aims: To describe the neurodevelopment of high-risk infants aged less than 1 year old, and to analyse the incidences and influencing factors of neurodevelopmental abnormalities in order to provide a basis for neurodevelopment monitoring and management of high-risk infants.

Insights into infancy weight gain patterns for term small-for-gestational-age babies.

Background: Too fast or slow weight gain in infancy is bad for health in later life. In this study, we aim to investigate the optimal weight gain pattern during the first 2 y of life for term small-for-gestational-age (SGA) infants.

Method: We employed data from a longitudinal, community-based cohort study on the growth and development of SGAs collected between 2004 and 2010 in Shanghai, China.

Catalytic Role of Conserved Asparagine, Glutamine, Serine, and Tyrosine Residues in Isoprenoid Biosynthesis Enzymes.

We report the results of an investigation into the catalytic role of highly conserved amide (asparagine, glutamine) and OH-containing (serine, tyrosine) residues in several prenyltransferases. We first obtained the X-ray structure of cyclolavandulyl diphosphate synthase containing two molecules of the substrate analog dimethylallyl ()-thiolodiphosphate (DMASPP). The two molecules have similar diphosphate group orientations to those seen in other ζ-fold (- head-to-tail and head-to-middle) prenyltransferases with one diphosphate moiety forming a bidentate chelate with Mg in the so-called S1 site (which is typically the allylic binding site in ζ-fold proteins) while the second diphosphate binds to Mg in the so-called S2 site (which is typically the homoallylic binding site in ζ-fold proteins) a single P1O1 oxygen.

The Crystal Structure of a Class of Cyclases that Catalyze the Cope Rearrangement.

Found recently in stignomatales, the Stig cyclases catalyze the Cope rearrangement and intramolecular cyclization to produce complex indole alkaloids. Five crystal structures were solved of subfamily 1 and 2 Stig cyclases, which adopt a β-sandwich fold like the non-catalytic carbohydrate-binding motif. Several complex structures were also determined of indole-based compounds, which are bound to the hydrophobic terminal cavity, where a conserved Asp residue makes an H-bond to the indole N and triggers the acid-catalyzed Cope rearrangement.

Growth of infants and young children born small for gestational age: growth restriction accompanied by overweight.

Objectives To compare growth profiles of children born small for gestational age (SGA) with those born the appropriate size for gestational age (AGA), and examine expected growth patterns for SGA in early childhood. Methods A survey on 23,871 SGA children was conducted in Shanghai. Data were collected at 1, 2, 4, 6, 8, 10, 12, 18, 24, 36, 48, and 60 months of age (+30 days).

Structural insight into a novel indole prenyltransferase in hapalindole-type alkaloid biosynthesis.

FamD1 is a novel CloQ/NphB-family indole prenyltransferase which involves in hapalindole-type alkaloid biosynthesis. Here the native FamD1 structure and three protein-ligand complexes are analyzed to investigate the molecular basis of substrate binding and catalysis. FamD1 adopts a typical ABBA architecture of aromatic prenyltransferase, in which the substrate-binding chamber is found in the central β-barrel.

"Head-to-Middle" and "Head-to-Tail" cis-Prenyl Transferases: Structure of Isosesquilavandulyl Diphosphate Synthase.

We report the first X-ray crystallographic structure of the "head-to-middle" prenyltransferase, isosesquilavandulyl diphosphate synthase, involved in biosynthesis of the merochlorin class of antibiotics. The protein adopts the ζ or cis-prenyl transferase fold but remarkably, unlike tuberculosinol adenosine synthase and other cis-prenyl transferases (e.g.

Characterization and crystal structure of a novel zearalenone hydrolase from Cladophialophora bantiana.

Zearalenone (ZEN) is a mycotoxin which causes huge economic losses in the food and animal feed industries. The lactonase ZHD101 from Clonostachys rosea, which catalyzes the hydrolytic degradation of ZEN, is the only known ZEN-detoxifying enzyme. Here, a protein homologous to ZHD101, denoted CbZHD, from Cladophialophora batiana was expressed and characterized.

A Village-Based Intervention: Promoting Folic Acid Use among Rural Chinese Women.

Background: Folic acid supplementation is effective in reducing the risk of neural tube defects (NTDs). However, the use of folic acid is low among rural women in China. Nutrition education can provide information about folic acid and encourage its use.

Capsinoids suppress fat accumulation via lipid metabolism.

Capsaicin, found in red peppers, has been reported to have anti‑obesity, anti‑hypertension, anti‑diabetes and anti‑inflammatory functions. In the present study, we determined the effect of non‑pungent capsinoids on the metabolism of adipocytes. We demonstrated that capsinoids suppressed fat accumulation in vivo and in vitro in mice.

[Growth follow-up of infants born macrosomia at their life of 0 to 18 months].

Objective: To study the growth of macrosomic infants, the incidence of overweight and the factors related to overweight at 18 months old.

Methods: Eighty-four macrosomic infants without underlying diseases were enrolled in this study. Their growth was followed up regularly.