Publications by authors named "Xiangyi Song"
Article Synopsis
- Disulfidptosis is a newly identified type of programmed cell death that results from disulfide stress, leading to the collapse of the cell's cytoskeleton, particularly in cancer cells with high levels of the protein SLC7A11.
- This process occurs when glucose deprivation causes excessive cystine import, depleting NADPH and increasing disulfide stress, which alters actin dynamics and results in cell death.
- The review emphasizes the importance of understanding the roles of SLC7A11 and its pathways in disulfidptosis, while also pointing out the need for further research to fully uncover how this mechanism affects tumors.
Evaluation of metal pollution characteristics using water and moss in the Luanchuan molybdenum mining area, China.
Environ Sci Pollut Res Int
January 2024
Luanchuan is rich in molybdenum resources, and mining activities are frequent, but over-mining can cause serious metal pollution to the local environment. To explore the degree of metal pollution caused by mining activities, the content characteristics and spatial distribution of metals in mining areas were studied by measuring the concentrations of Fe, Mn, Zn, Ba, Mo, Cu, Cr, Co, V, and W in surface water and mosses of mining areas. In addition, the metal pollution index (HPI), contamination factor (CF), and pollution load index (PLI) were used to evaluate metal pollution, and factor analysis was used to analyze the sources of metals.
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- Immune reconstitution inflammatory syndrome (IRIS) occurs when the immune system rebounds, leading to excessive inflammation, and can be associated with various infections, including HIV and Whipple disease (WD).
- WD is caused by a specific bacterium and IRIS can complicate its treatment, yet its unique features are not well explored in medical literature.
- Recent studies on the immune response in the intestines have shed light on IRIS in WD, suggesting potential new approaches for monitoring and treating this syndrome.
Immunotherapy via immune checkpoints blockade has aroused the attention of researchers worldwide. Inhibition of the programmed cell death-1 (PD-1)/programmed cell death-ligand 1 (PD-L1) interaction has been one of the most promising immunotherapy strategies. Several neutralizing antibodies targeting this interaction have been developed, which have already achieved considerable clinical success.
View Article and Find Full Text PDFBackground: Tumor recurrence in patients after surgery severely reduces the survival rate of surgical patients. Targeting and killing recurrent tumor cells and tissues is extremely important for the cancer treatment.
Results: Herein, we designed a nano-biomimetic photothermal-controlled drug-loading platform HepM-TSL with good targeting ability and immunocompatibility for the treatment of recurrent hepatocellular carcinoma.