Publications by authors named "Xiangyang Shao"
Article Synopsis
- A fluorescence lateral flow immunoassay (F-LFIA) using nanoparticles with encapsulated molecules is developed to detect gastrin-releasing peptide precursor (proGRP) in serum samples.
- The F-LFIA was optimized to have a detection range of 10 to 5000 pg/mL, with a low detection limit of 6 pg/mL, and demonstrated excellent sensitivity, specificity, and reproducibility.
- In tests on 183 human serum samples, the F-LFIA results correlated well with standard electrochemiluminescence immunoassays, showing promise for early detection of small-cell lung cancer (SCLC).
Objevtive: To investigate the effects of Cyclocarya paliurus (C. paliurus) polysaccharides on the spleen injury of diabetic rats.
Methods: Animals were divided into 6 groups, including normal group, model group, control group, low-dose group of C.
Background: YTH domain family (YTHDF) 2 acts as a "reader" protein for RNA methylation, which is important in tumor regulation. However, the effect of YTHDF2 in liver hepatocellular carcinoma (LIHC) has yet to be elucidated.
Methods: We explored the role of YTHDF2 in LIHC based on publicly available datasets [The Cancer Genome Atlas (TCGA), International Cancer Genome Consortium (ICGC), and Gene Expression Omnibus (GEO)].
Objevtive: To investigate the efficacy of Cyclocarya paliurus (C. paliurus) polysaccharides on stre- ptozotocin-induced diabetic nephropathy in rats.
Methods: Rats were divided into 6 groups, including group of normal control, group of diabetic control, group of metformin treatment, low-dose group of C.
Background: Increasing evidence suggests that aberrant alternative splicing (AS) events are associated with progression of cancer. This study evaluated the prognostic value and clarify the role of AS events in cervical cancer (CC).
Methods: Based on RNA-seq AS event data and clinical information of CC patients in The Cancer Genome Atlas (TCGA) database, we sought to identify prognosis-related AS events in this setting.
Article Synopsis
- The study aimed to evaluate the effectiveness of glypican-3 (GPC3), arginase-1 (Arg-1), and hepatocyte paraffin antigen 1 (HepPar-1) as biomarkers for distinguishing hepatocellular carcinoma (HCC) from intrahepatic cholangiocarcinoma (ICC).
- Using immunohistochemistry, the researchers measured the expression levels of these biomarkers in 47 HCC cases and 29 ICC cases, finding significantly higher expression in HCC compared to ICC.
- The study concluded that combining GPC3, Arg-1, and HepPar-1 significantly increases diagnostic sensitivity and specificity for HCC, suggesting their joint use could enhance differentiation between these cancer types
Introduction: Dexmedetomidine (DEX) has been demonstrated to inhibit inflammatory response and protect against multiorgan injury in various scenarios. The objectives of the present study were to ascertain whether DEX is able to attenuate acute lung injury (ALI) under heatstroke (HS), and to explore the underlying mechanism.
Methods: Male C57BL/6 mice were exposed to ambient temperature of 39.
Inflammation and immunity are important determinants of cancer initiation, promotion, and progression to cancer equilibrium or suppression. The NOD-like receptor family pyrin domain containing 3 (NLRP3) is an oligomeric intracellular immune receptor, and the main component of inflammasome. As a widely distributed effector of innate immunity, NLRP3 inflammasome affects development of many cancer types, but its exact role in colorectal cancer (CRC) is controversial.
View Article and Find Full Text PDFRecently, accumulating evidence from clinical and experimental researches have suggested that translationally controlled tumor protein (TCTP) and high mobility group box 1 (HMGB1) are implicated in colorectal cancer (CRC) metastasis. However, whether there is an interconnection between these two tumor-promoting proteins and how they affect CRC metastasis remain to be fully elucidated. In the present study, the expression level of TCTP in CRC tissues was assessed by immunohistochemical staining and immunoblotting, and the serum concentration of HMGB1 in patients with CRC was detected by enzyme-linked immunosorbent assay.
View Article and Find Full Text PDFProcalcitonin (PCT) is a current, frequently-used marker for severe bacterial infection. The aim of this study was to develop a cost-effective detection kit for rapid quantitative and on-site detection of PCT. To develop the new PCT quantitative detecting kit, a double-antibody sandwich immunofluorescent assay was employed based on time-resolved immunofluorescent assay (TRFIA) combined with lateral flow immunoassay (LFIA).
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