Quantitative risk assessment of rainstorm-induced flood disaster in Piedmont plain of Pakistan.

Pakistan's geographic location makes it an important land hub between Central Asia, Middle East-North Africa, and China. However, the railways, roads, farmland, riverways, and residential quarters in the Piedmont plains of Baluchistan province in northwestern Pakistan are under serious threat of flooding in the summer of 2022. The urgency and severity of climate change's impact on humanity are underscored by the significant threats posed to human life and property in Piedmont Plains environments through extreme flood events, which has garnered widespread concerns.

Combining geophysics, remote sensing and numerical simulation to assess GLOFs: Case study of the Namulacuo Lake in the Southeastern Tibetan Plateau.

The current highest glacial lake outburst floods (GLOFs) risk level is centered in the eastern Himalaya. GLOFs represent a serious threat to downstream inhabitants and ecological environment. In the context of climate warming on the Tibetan Plateau, such GLOFs will continue or even intensify in the future.

Imminent threat of rock-ice avalanches in High Mountain Asia.

Upsurge of glacier-related hazards in High Mountain Asia (HMA) has been evident in recent years due to global warming. While many glacial-related hazards are instantaneous, some large landslides were preceded by slow gravitational deformation, which can be predicted to evade catastrophes. Here, we present robust evidence of historical deformation in 2021 Chamoli rock-ice avalanche of Himalaya using space imaging techniques.

Physcion 8-O-β-glucopyranoside inhibits testicular germ cell tumors through regulating microRNA-199a.

Testicular germ cell tumors (TGCTs) are frequently diagnosed solid tumors in young adult males. The present study aimed to investigate the anti-tumor function of Physcion 8-O-β-Glucopyranoside (PG) in TGCTs, and to explore the underlying anti-tumor mechanism of PG in TGCTs. Cell viability was measured by a cell counting kit-8 (CCK-8) assay, and the cell cycle distribution was analyzed by flow cytometry.