Prognostic Impact of Serum Homocysteine-Lowering Therapy on Patients with Hemorrhagic Stroke and Its Influence on National Institutes of Health Stroke Scale and China Stroke Scale Scores.

Objective: This study aimed to investigate the prognostic impact of serum homocysteine-lowering therapy on patients with hemorrhagic stroke (HS) and its influence on their National Institutes of Health Stroke Scale (NIHSS) and China Stroke Scale (CSS) scores.

Methods: A double-blind study involving 120 patients with HS and hyperhomocysteinemia (Hhcy) who were admitted to our hospital was conducted in 2021. They were evenly divided into two groups: the control group (n=60) received low-dose folic acid, methylcobalamin, and vitamin B6 as part of serum homocysteine-lowering therapy, while the study group (n=60) received high-dose folic acid, methylcobalamin, and vitamin B6.

Circular RNA circTIE1 drives proliferation, migration, and invasion of glioma cells through regulating miR-1286/TEAD1 axis.

Recent studies have verified that circRNAs (circular RNAs) play a critical role in glioma occurrence and malignant progression. However, numerous circRNAs with unknown functions remain to be explored with further research. qPCR (quantitative real-time polymerase chain reaction) was employed to detect circTIE1 expression in glioma tissues, NHAs (normal human astrocytes), and glioma cellular lines (U87, U118, U251, T98G, LN229).

The Preparation of CuInS-ZnS-Glutathione Quantum Dots and Their Application on the Sensitive Determination of Cytochrome and Imaging of HeLa Cells.

Cytochrome (Cyt ), one of the most significant proteins acting as an electron transporter, plays an important role during the transferring process of the energy in cells. Apoptosis, one of the major forms of cell death, has been associated with various physiological regularity and pathological mechanisms. It was found that Cyt can be released from mitochondria to cytosol under different pathological conditions, triggering subsequent cell apoptosis.

The hydrophilic boronic acid-poly(ethylene glycol) methyl ether methacrylate copolymer brushes functionalized magnetic carbon nanotubes for the selective enrichment of glycoproteins.

An efficient and selective glycoproteins enrichment platform is essential to glycoprotein biomarkers in early clinic diagnostics. In this work, the poly (ethylene glycol) methyl ether methacrylate (PEGMA) and 4-vinylphenylboronic acid (VPBA) copolymer brushes grafted magnetic carbon nanotubes composite MCNTs@p (PEGMA-co-VPBA) was prepared by surface-initiated atom transfer polymerization and applied for the selective enrichment of glycoproteins from the complex biological samples. The as-prepared MCNTs@p (PEGMA-co-VPBA) nanocomposite was characterized by Fourier transform-infrared spectroscopy (FTIR), transmission electron microscopy (TEM), X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS) and vibrating sample magnetometry (VSM).

Graphene oxide-based boronate polymer brushes via surface initiated atom transfer radical polymerization for the selective enrichment of glycoproteins.

Biomedical sciences, and in particular biomarker research, demand efficient glycoprotein enrichment platforms. In this work, a facile and efficient method was developed to synthesize boronic acid polymer brushes immobilized on magnetic graphene oxide via surface initiated atom transfer radical polymerization (SI-ATRP) for the selective enrichment of glycoproteins from complex biological samples. The magnetic graphene oxide (GO@FeO) nanocomposites were prepared by a solvothermal reaction, providing an ultrahigh surface area and allowing fast separation.