Publications by authors named "Xiangyan Ai"
Article Synopsis
- Colitis is an inflammatory intestinal disease that affects patients' quality of life and is often hard to treat, with factors like infections and inflammation playing a major role.
- The study tested the effects of 5-methoxytryptophan (5-MTP) in a mouse model of colitis, finding it reduces inflammation by inhibiting macrophage infiltration and damaging tight junctions of intestinal cells.
- Results indicate that 5-MTP effectively combats inflammation and cell death, suggesting it could be a promising treatment for colitis.
Primary Sjögren's syndrome (pSS) is a progressive systemic autoimmune disease characterized by lymphocytic infiltrates in exocrine glands, leading to the injury of salivary and lachrymal glands. Mesenchymal stem cells (MSCs) have been demonstrated to exert great potential in the treatment of various autoimmune diseases. Although MSCs have provide an effective therapeutic approach for SS treatment, the underlying mechanisms are still elusive.
View Article and Find Full Text PDFBackground And Aims: The aim of this study is to investigate the expression pattern of histone deacetylase 9 in peripheral blood of patients with allergic asthma and its regulatory effect on the balance of Th17/Treg cells involved in the pathogenesis of asthma.
Methods: flap-Ub promoter-GFP-WRE vector was used to construct the Jurkat-HA-FOXP3 cell line. After histone deacetylase inhibitor-trichostatin A (TSA) treatment, FOXP3 and RORγt expression were detected by real-time-polymerase chain reaction (RT-PCR).
Article Synopsis
- * It finds that patients with moderate to severe asthma have fewer Treg cells and lower levels of interleukin-10 compared to healthy individuals, while Th2 cells and interleukin-4 are higher.
- * The results suggest that an imbalance favoring Th2 cells over Treg cells could contribute to the worsening of asthma symptoms in these patients.
[Characteristics of histone deacetylase 9 in peripheral blood of patients with bronchial asthma].
Zhonghua Jie He He Hu Xi Za Zhi
May 2012
Objective: To investigate the expression pattern of histone deacetylase 9 (HDAC9) in peripheral blood of asthmatics and its effect on immune cells (Th2, Th17, Tregs) involved in the pathogenesis of asthma.
Methods: Forty-seven asthmatics from Ruijin Hospital were recruited and assigned to intermittent, mild and moderate-severe groups. Lung function test and Asthma Control Questionnaire were performed to evaluate asthma control and severity.
Background: Recent recognition is that Th2 response is insufficient to fully explain the aetiology of asthma. Other CD4(+) T cells subsets might play a role in asthma. We investigated the relative abundance and activities of Th1, Th2, Th17 and CD4(+)CD25(+) Treg cells in patients with allergic asthma.
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