Insights into enhanced immobilization of uranyl carbonate from seawater by Fe-doped MXene.

Extracting uranium from seawater not only reduces radioactive contamination in seawater but also provides a source of uranium energy. However, due to the low concentration of uranium in seawater and the high salinity of seawater, extraction of uranium from seawater is challenging. In this work, we demonstrated a simple strategy to synthesize Fe-doped MXene (Fe@TiCT) via a hydrothermal method and applied for uranium enrichment in seawater.

Object detection: A novel AI technology for the diagnosis of hepatocyte ballooning.

Metabolic dysfunction-associated fatty liver disease (MAFLD) has reached epidemic proportions worldwide and is the most frequent cause of chronic liver disease in developed countries. Within the spectrum of liver disease in MAFLD, steatohepatitis is a progressive form of liver disease and hepatocyte ballooning (HB) is a cardinal pathological feature of steatohepatitis. The accurate and reproducible diagnosis of HB is therefore critical for the early detection and treatment of steatohepatitis.

Single-cell morphological and topological atlas reveals the ecosystem diversity of human breast cancer.

Digital pathology allows computerized analysis of tumor ecosystem using whole slide images (WSIs). Here, we present single-cell morphological and topological profiling (sc-MTOP) to characterize tumor ecosystem by extracting the features of nuclear morphology and intercellular spatial relationship for individual cells. We construct a single-cell atlas comprising 410 million cells from 637 breast cancer WSIs and dissect the phenotypic diversity within tumor, inflammatory and stroma cells respectively.

Rational design of MOF@COF composites with multi-site functional groups for enhanced elimination of U(VI) from aqueous solution.

Both environment and human beings were menaced by the widespread application of radioactive uranium, high-performance and effective elimination of uranium from wastewater is of important meaning for development of environmental sustainability in the future. In this study, the water-stable MOF material and the highly crystalline COF were compounded by a mild hydrothermal strategy, which achieved efficient removal of U(VI) through the synergistic effect. The composites showed the characteristics of both COFs and MOFs, which will possess higher stability, larger surface area and faster adsorption efficiency that cannot be carried out by a single component.

Influence of humic acid on U(VI) elimination by ZIF-8: Synergistic chemical effect.

ZIF-8, a sort of zeolitic imidazolate frameworks (ZIFs), had showed superior adsorptive property of typical radionuclide U(VI), but it reminded uncertain how the performance of ZIF-8 would be affected by adding humic acid (HA). HA could significantly change the surface charge of ZIFs and the transport of U(VI) in natural settings, which affected the eradication of U(VI) in aquatic ecology. Thus the impact of HA for the U(VI) removal by ZIF-8 as well as its mechanism had been analyzed by batch experiments and spectral analyses.

CT radiomic signature predicts survival and chemotherapy benefit in stage I and II HPV-associated oropharyngeal carcinoma.

Chemoradiation is a common therapeutic regimen for human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma (OPSCC). However, not all patients benefit from chemotherapy, especially patients with low-risk characteristics. We aim to develop and validate a prognostic and predictive radiomic image signature (pRiS) to inform survival and chemotherapy benefit using computed tomography (CT) scans from 491 stage I and II HPV-associated OPSCC, which were divided into three cohorts D-D.

A review of iodine in plants with biofortification: Uptake, accumulation, transportation, function, and toxicity.

Iodine deficiency can cause thyroid disease, a serious health problem that has been affecting humans since several years. The biofortification of plants with iodine is an effective strategy for regulating iodine content in humans. In addition, radioiodine released into the atmosphere may contaminate terrestrial ecosystem along with dry or wet deposition and its accumulation in plants may cause exposure risks to humans via food chain.

[Multi-tissue segmentation model of whole slide image of pancreatic cancer based on multi task and attention mechanism].

Accurate segmentation of whole slide images is of great significance for the diagnosis of pancreatic cancer. However, developing an automatic model is challenging due to the complex content, limited samples, and high sample heterogeneity of pathological images. This paper presented a multi-tissue segmentation model for whole slide images of pancreatic cancer.

Highly efficient extraction of uranium from seawater by polyamide and amidoxime co-functionalized MXene.

Uranium mainly exists in the form of uranyl carbonate in seawater. [UO(CO)] has strong stability, which increases the difficulty of uranium extraction from seawater. Meanwhile, the complex marine environment, a large number of coexisting competing ions and biological pollution are all non-negligible disturbing factors.

A novel pipeline for computerized mouse spermatogenesis staging.

Motivation: Differentiating 12 stages of the mouse seminiferous epithelial cycle is vital towards understanding the dynamic spermatogenesis process. However, it is challenging since two adjacent spermatogenic stages are morphologically similar. Distinguishing Stages I-III from Stages IV-V is important for histologists to understand sperm development in wildtype mice and spermatogenic defects in infertile mice.

Melatonin Ameliorates the Progression of Alzheimer's Disease by Inducing TFEB Nuclear Translocation, Promoting Mitophagy, and Regulating NLRP3 Inflammasome Activity.

Background: The NLRP3 inflammasome is overactivated in the brains of APP/PS1 transgenic mice and AD patients, and mitophagy has an obvious negative regulatory role on NLRP3 inflammasome activation. The protective effect of melatonin in AD may be related to the regulation of mitophagy and NLRP3 inflammasome activity. TFEB plays a critical role in maintaining autophagy/mitophagy.

Spatial interplay patterns of cancer nuclei and tumor-infiltrating lymphocytes (TILs) predict clinical benefit for immune checkpoint inhibitors.

Immune checkpoint inhibitors (ICIs) show prominent clinical activity across multiple advanced tumors. However, less than half of patients respond even after molecule-based selection. Thus, improved biomarkers are required.

Survival prediction on intrahepatic cholangiocarcinoma with histomorphological analysis on the whole slide images.

Intrahepatic cholangiocarcinoma (ICC) is cancer that originates from the liver's secondary ductal epithelium or branch. Due to the lack of early-stage clinical symptoms and very high mortality, the 5-year postoperative survival rate is only about 35%. A critical step to improve patients' survival is accurately predicting their survival status and giving appropriate treatment.

Deep SED-Net with interactive learning for multiple testicular cell types segmentation and cell composition analysis in mouse seminiferous tubules.

The development of mouse spermatozoa is a continuous process from spermatogonia, spermatocytes, spermatids to mature sperm. Those developing germ cells (spermatogonia, spermatocyte, and spermatids) together with supporting sertoli cells are all enclosed inside seminiferous tubules of the testis, their identification is key to testis histology and pathology analysis. Automated segmentation of all these cells is a challenging task because of their dynamical changes in different stages.

Effect of Shewanella oneidensis MR-1 on U(VI) sequestration by montmorillonite.

Bacteria may change the physicochemical properties of montmorillonite and further effect the disposal of high-level radioactive waste. Therefore, we explored the influence of Shewanella oneidensis MR-1 on the elimination of representative radionuclide U(VI) by montmorillonite (MMT). The batch experiments showed that MR-1 significantly enhanced the removal efficiency of U(VI), the adsorption capacity of MMT improved from 8.

Bismuth oxychloride-based materials for the removal of organic pollutants in wastewater.

Various kind of organics are toxic and detrimental, resulting in eutrophication, black, odorous water and so on. Photocatalysis has been deemed to be a promising technology which can decompose different kinds of organic pollutants under visible light irradiation, finally achieving non-poisonous, harmless CO, water and other inorganic materials. Bismuth oxychloride (BiOCl) is considered as a promising photocatalyst for the efficient degradation of organic pollutants due to its high chemical stability, unique layered structure, resistance to corrosion and favorable photocatalytic property.

Applications of water-stable metal-organic frameworks in the removal of water pollutants: A review.

Because the pollutants produced by human activities have destroyed the ecological balance of natural water environment, and caused severe impact on human life safety and environmental security. Hence the task of water environment restoration is imminent. Metal-organic frameworks (MOFs), structured from organic ligands and inorganic metal ions, are notable for their outstanding crystallinity, diverse structures, large surface areas, adsorption performance, and excellent component tunability.

Recent advances in metal-organic framework membranes for water treatment: A review.

Among many separation membranes reported to date, the favorable polymer affinity and unique physio-chemical performances of metal-organic frameworks (MOFs) including ultra-high surface area, regular and highly controlled porosity have drawn widespread attention in industrial and academic communities. In this comprehensive review, the developmental timeline of MOF containing membranes for water treatment were clarified. The removal efficiencies, elimination mechanisms, as well as possible influencing factors of various MOF containing membranes that applied to water treatment were systematically summarized.

A prognostic and predictive computational pathology image signature for added benefit of adjuvant chemotherapy in early stage non-small-cell lung cancer.

Background: We developed and validated a prognostic and predictive computational pathology risk score (CoRiS) using H&E stained tissue images from patients with early-stage non-small cell lung cancer (ES-NSCLC).

Methods: 1330 patients with ES-NSCLC were acquired from 3 independent sources and divided into four cohorts D. D comprised 100 surgery treated patients and was used to identify prognostic features via an elastic-net Cox model to predict overall and disease-free survival.

Computerized spermatogenesis staging (CSS) of mouse testis sections via quantitative histomorphological analysis.

Spermatogenesis in mammals is a cyclic process of spermatogenic cell development in the seminiferous epithelium that can be subdivided into 12 subsequent stages. Histological staging analysis of testis sections, specifically of seminiferous tubule cross-sections, is the only effective method to evaluate the quality of the spermatogenic process and to determine developmental defects leading to infertility. Such staging analysis, however, is tedious and time-consuming, and it may take a long time to become proficient.

Feature-driven local cell graph (FLocK): New computational pathology-based descriptors for prognosis of lung cancer and HPV status of oropharyngeal cancers.

Local spatial arrangement of nuclei in histopathology images of different cancer subtypes has been shown to have prognostic value. In order to capture localized nuclear architectural information, local cell cluster graph-based measurements have been proposed. However, conventional ways of cell graph construction only utilize nuclear spatial proximity, and do not differentiate between different cell types while constructing the graph.