Experimental Study on Acoustic Emission Features and Energy Dissipation Properties during Rock Shear-Slip Process.

The features of rock shear-slip fracturing are closely related to the stability of rock mass engineering. Granite, white sandstone, red sandstone, and yellow sandstone specimens were selected in this study. The loading phase of "shear failure > slow slip > fast slip" was set up to explore the correlation between fracture type, acoustic emission (AE) features, and energy dissipation during the rock fracturing process.

GLP-1 plays a protective role in hippocampal neuronal cells by activating cAMP-CREB-BDNF signaling pathway against CORT+HG-induced toxicity.

Major depressive disorder (MDD) with diabetes mellitus (DM) significantly reduces the quality of the patient's life, and currently, there is no effective treatment. This study explored the feasibility of Glucagon-like peptide-1 (GLP-1) in treating MDD combined with DM. The protective effects of GLP-1 on mouse hippocampal neuronal cell line HT22 cultured with corticosterone (CORT) and high glucose (HG) were assessed.

The impact of oxygen on Ga doped ZnO film.

The Ga doped ZnO (GZO) film is one of the promising alternative films to replace ITO film, but its properties suffer from degradation when it is deposited under oxygen-rich conditions. This degradation has been investigated by depositing the films under different oxygen partial pressures. XRD results showed that all GZO films had wurtzite structure and the lattice parameter- contracted when oxygen was introduced into the argon deposition atmosphere, but the parameter- nearly remained constant when oxygen partial pressures were further increased.

Association of Social Isolation and Loneliness With Incident Heart Failure in a Population-Based Cohort Study.

Background: Social isolation and loneliness have emerged as important risk factors for cardiovascular diseases, particularly during the coronavirus disease pandemic. However, it is unclear whether social isolation and loneliness had independent and joint associations with incident heart failure (HF).

Objectives: This study sought to examine the association of social isolation, loneliness, and their combination with incident HF.

Predictive Value Analysis of Serum Ig A, Ig G, and TNF- in Recurrence of Multiple Myeloma.

Objective: The study is aimed at analyzing the predictive value of serum Ig A, Ig G, and TNF- in the recurrence of multiple myeloma (MM).

Methods: 136 patients with MM treated in our hospital from January 2010 to January 2017 were followed up for 5 years. Finally, 100 patients who met the inclusion and exclusion criteria and had the complete follow-up visit were selected as the study subjects, with the recurrence of MM as endpoint event, and the observation was taken until the occurrence of endpoint event in patients or the termination of this study.

Characterization of Sputtered CdTe Thin Films with Electron Backscatter Diffraction and Correlation with Device Performance.

The performance of polycrystalline CdTe photovoltaic thin films is expected to depend on the grain boundary density and corresponding grain size of the film microstructure. However, the electrical performance of grain boundaries within these films is not well understood, and can be beneficial, harmful, or neutral in terms of film performance. Electron backscatter diffraction has been used to characterize the grain size, grain boundary structure, and crystallographic texture of sputtered CdTe at varying deposition pressures before and after CdCl2 treatment in order to correlate performance with microstructure.

Inhibitory effects and molecular mechanisms of garlic organosulfur compounds on the production of inflammatory mediators.

Scope: Garlic is used for both culinary and medicinal purposes by many cultures. The garlic organosulfur compounds (GOSCs) are thought to be bioactive components. This study aims to clarify the antiinflammatory effects and molecular mechanisms of GOSCs in both cell and animal models.

[Relations between serum homocysteinemia and carotid artery plaques].

Objective: To explore the relation between homocysteinemia (HCY) and carotid artery plaque.

Methods: Subjects were derived from a cohort of Kailuan study, which was a community-based and cross-sectional. From June 2010 to June 2011, a total of 5852 subjects were selected from 101 510 working or retired employees at the Tangshan Kailuan Company in 2006 - 2007.

[Study on the inhibit mechanism primarily of extracts from Coptis on clinical resistant the medicine of Staphylococcus aureus].

Objective: To discuss the inhibit mechanism primarily of extracts from Coptis on clinical resistant the medicine of Staphylococcus aureus.

Methods: Used SDS-PAGE electrophoresis, spectrophotometry and semiautomatic biochemistry analysis to detect the accumulated concentration of norfloxacin, membranin electrophoretogram and the enzymatic activity in extracellular fluid before and after Coptis extract disposition.

Results: The accumulated concentration of medicine norfloxacin within the experiment strains which treated with Coptis extract was clear higher than that of the blank space (P < 0.

Expression, purification, and characterization of recombinant human keratinocyte growth factor-2 in Pichia pastoris.

Keratinocyte growth factor-2 (KGF-2) is a member of the fibroblast growth factor family. The full-length human KGF-2 coding sequence, gained by synthesizing, was cloned into the pPICZalphaA vector in frame with the yeast alpha-factor secretion signal under the transcriptional control of the AOX promoter and integrated into Pichia pastoris strain GS115. In shake-flask culture induced with methanol, the rhKGF-2 content was about 17.

Removal of antibiotic resistance of live vaccine strain Escherichia coli MM-3 and evaluation of the immunogenicity of the new strain.

MM-3 was a live vaccine strain candidate for protecting neonatal piglets from diarrhea. Designed in the 1980s, a high degree of protection from colibacillosis was afforded to piglets in a challenge study and field trials. However MM-3 had a drawback of carrying the antibiotic resistance gene (chloramphenicol acetyltransferase gene, cat).

Construction of a novel Shigella live-vector strain co-expressing CS3 and LTB/STm of enterotoxigenic E.coli.

Aim: To construct and evaluate a polyvalent recombinant vaccine strain Shigella flexneri 2a T32 against enterotoxigenic E.coli (ETEC).

Methods: By using a host-plasmid balanced lethal system based on asd gene, a polyvalent recombinant strain was constructed to highly express CS3 and regularly express fusion enterotoxin of LTB subunit and mutant ST (LTB/STm) in a vaccine strain Shigella flexneri 2a T32 with specific deletion of asd gene.

[Effects of intermittent normobaric hypoxia training on heart rate variability].

Objective: To observe the influences of intermittent normobaric hypoxia (INH) training on heart rate variability (HRV) under hypoxia.

Method: Eight subjects were trained with INH for 4 weeks (24 d), subjects' HRV level, recorded during exposure to hypoxia (10% O2) before and after the training, were compared and analyzed.

Result: After the INH training, average of normal to normal Intervals (R-R), standard deviation of normal to normal Intervals (SDNN), total power (TP), high frequency (HF) and low frequency (LF) increased significantly during hypoxia (P<0.