Publications by authors named "Xiangxiang Shao"
Open Med (Wars)
June 2024
Article Synopsis
- This research investigates how H2Valdien derivatives affect the growth, movement, and death of liver cancer cells (HepG2, Huh-7, and SMMC-7721), focusing on how they may prevent a process called epithelial-mesenchymal transition (EMT).
- Using various laboratory methods, the study found that these derivatives can halt cell growth and promote cell death in a dose-dependent way, while also reducing the ability of cancer cells to migrate and invade other tissues.
- The study highlights that H2Valdien derivatives work by inhibiting the Hedgehog (Hh) signaling pathway, which is critical for cancer cell behavior, suggesting their potential as a treatment for liver cancer by targeting EMT regulation.
