BDNF is a prognostic biomarker involved in immune infiltration of lung adenocarcinoma and is associated with brain metastasis.

Non-small cell lung cancer (NSCLC) is one of the leading causes of death worldwide. Brain metastases are a common complication of a wide range of human malignancies, particularly lung adenocarcinoma (LUAD). Brain-derived neurotrophic factor (BDNF), a member of the neurotrophin family, has been linked to several human malignancies and has been shown to promote LUAD tumorigenesis.

Molecular mechanism of lncRNA SNHG12 in immune escape of non-small cell lung cancer through the HuR/PD-L1/USP8 axis.

Background: The pivotal role of long noncoding RNAs (lncRNAs) in cancer immune responses has been well established. This study was conducted with the aim of exploring the molecular mechanism of lncRNA small nucleolar RNA host gene 12 (SNHG12) in immune escape of non-small cell lung cancer (NSCLC).

Methods: Expression of lncRNA SNHG12, programmed cell death receptor ligand 1 (PD-L1), ubiquitin-specific protease 8 (USP8), and human antigen R (HuR) in NSCLC tissues and cells was measured, and their binding relationship was determined.

[Antimony dietary exposure and health risk assessment to children and adolescent in Hunan Province during 2014-2015].

Objective: To evaluate the dietary exposure level and health risk of antimony of children and adolescent in Hunan Province.

Methods: The content of antimony of main food were determined. The dietary exposure of children and adolescent from Hunan was calculated according to the weight and intake from Survey Report on Nutrition and Health Status of Chinese Residents Part 10: Nutrition and Health Data in2002 and combing the data of average and the 95% percentile of antimony.