Publications by authors named "Xiangwen Dong"
Article Synopsis
- A clinical trial assessed the safety and effectiveness of AAV8-hCARp.hCNGB3 gene therapy in treating CNGB3-associated achromatopsia (ACHM) in 23 participants, including adults and children.
- Participants received varying doses of the treatment in their worst-seeing eye, with corticosteroids given to manage any inflammation.
- While the therapy showed an acceptable safety profile, with mild to moderate inflammation in some cases, there were individual improvements in color vision and quality of life, suggesting potential benefits warranting further research.
Background: The Fontan procedure is the final step of the 3-stage palliative procedure commonly performed in children with single ventricle physiology. Thrombosis remains an important complication in children after this procedure. To date, guideline recommendations for the type and duration of thromboprophylaxis after Fontan surgery are mainly based on extrapolation of knowledge gained from adults at risk for thrombosis in other clinical settings.
View Article and Find Full Text PDFSubcellular localization of Ras proteins to the plasma membrane is accomplished in part by covalent attachment of a farnesyl moiety to the conserved CaaX box cysteine. Farnesylation targets Ras to the endoplasmic reticulum (ER), where additional processing steps occur, resulting in translocation of Ras to the plasma membrane. The mechanism(s) by which this occurs is not well understood.
View Article and Find Full Text PDFArticle Synopsis
- Ras oncogene proteins are crucial signal transducers in eukaryotic cells that require lipid modification to localize to the plasma membrane.
- Mutations in the genes ERF2 and ERF4/SHR5 impact the palmitoylation and positioning of Ras proteins, highlighting their role in the localization pathway.
- The study identifies Erf4p and Erf2p as part of a novel transport pathway that facilitates the proper targeting of Ras proteins to the plasma membrane, distinct from traditional secretion routes.