Ginsenoside reprogramming microglia through the FGF/FGFR1 inhibits post traumatic stress disorder.

Post traumatic stress disorder (PTSD) is a serious and persistent mental diseases. Nowadays, Treatment of PTSD patients in clinical practice is mainly based on drug therapy accompanied by psychological therapy. However, the therapeutic effect is unsatisfactory.

Electrosynthesis of γ-Butyrolactones by Dehydrogenative (3+2) Annulation.

The synthetic research for building γ-butyrolactones is being developed due to the high value of lactone skeletons, commonly found in natural products, functional molecules, bioactive agents and pharmaceuticals. However, reported synthetic methods, including harsh conditions, reliance on volatile activating reagents, and using noble metals, remain challenging. In this work, we present an electro-oxidative (3+2) annulation of alkenes with 1,3-diesters, offering an efficient route to γ-butyrolactones.

Greenhouse gas emissions from Boreal Lakes: Highlighting the impact of salinity and freezing period on emission dynamics.

Lakes and ponds in boreal regions are considerable natural sources of greenhouse gases (GHGs), including carbon dioxide (CO₂), methane (CH₄) and nitrous oxide (N₂O). Although the seasonal variability of GHG emissions from boreal lakes is crucial for improving global emission models, emissions during the freezing period have not received sufficient attention. Focusing on two representative boreal lakes in China-Ulansuhai and Daihai-this study investigated variations in GHG emissions during both the non-freezing and freezing periods.

Delving into nitrogen and phosphorus dynamics in shallow eutrophic lakes: Multi-interface response to freeze-thaw cycles.

Assessing the impact of freeze-thaw cycles on nutrient transfer in lakes is crucial for addressing the global eutrophication of freshwater ecosystems in cold and arid regions. However, available information about the dynamics of nitrogen (N) and phosphorus (P) release during intact freeze-thaw cycles, especially in the sediment-porewater-water column continuum of lakes, is limited. This study collected the samples during ice-covered (January) and non-ice-covered (April, July, and October) periods.

mTOR mutation disrupts larval zebrafish tail fin regeneration via regulating proliferation of blastema cells and mitochondrial functions.

Background: The larval zebrafish tail fin can completely regenerate in 3 days post amputation. mTOR, the main regulator of cell growth and metabolism, plays an essential role in regeneration. Lots of studies have documented the role of mTOR in regeneration.

Highly Ordered Nanotube-Like Microstructure on Titanium Dental Implant Surface Fabricated via Anodization Enhanced Cell Adhesion and Migration of Human Gingival Fibroblasts.

Background: Titanium (Ti) surface with nanotubes array via anodization has been used in dental implants to enhance bone regeneration but little research was carried out to evaluate whether the presence of highly ordered or disorderly distributed nanotubes array on titanium surface would have an effect on cell behaviors of gingival fibroblasts.

Methods: The present study fabricated nanotubes arrays with varied topography under different constant voltage of electrochemical anodization in fluorine-containing electrolyte. Human gingival fibroblasts (HGFs) from extracted third molar were harvested and co-cultured with titanium disks with different nanotubes topography.

Tracing spatial patterns of lacustrine groundwater discharge in a closed inland lake using stable isotopes.

Tracing lacustrine groundwater discharge (LGD) is essential for understanding the hydrological cycle and water chemistry behaviour of lakes. LGD usually exhibits large spatial variability, but there are few reports on quantitatively revealing the spatial patterns of LGD at the whole lake scale. This study investigated the spatial patterns of LGD in Daihai Lake, a typical closed inland lake in northern China, based on the stable isotopes (δH and δO) of groundwater, surface water, and sediment pore water (SPW).

Outcomes After Double-Layer Repair Versus En Masse Repair for Delaminated Rotator Cuff Injury: A Systematic Review and Meta-analysis.

Background: Delamination of rotator cuff tears during arthroscopic shoulder surgery has an incidence of 38% to 92%. Double-layer (DL) repair and en masse (EM) repair are most commonly used in this situation.

Purpose: To compare the clinical results of the DL versus EM repair techniques for delaminated rotator cuff tears using a meta-analysis.

Significant methane ebullition from large shallow eutrophic lakes of the semi-arid region of northern China.

Eutrophic lakes are a major source of the atmospheric greenhouse gas methane (CH), and CH ebullition emissions from inland lakes have important implications for the carbon cycle. However, the spatio-temporal heterogeneity of CH ebullition emission and its influencing factors in shallow eutrophic lakes of arid and semi-arid regions remain unclear. This study aimed to determine the mechanism of CH emission via eutrophication in Lake Ulansuhai, a large shallow eutrophic lake in a semi-arid region of China.

Greenhouse gas emissions from Daihai Lake, China: Should eutrophication and salinity promote carbon emission dynamics?

Greenhouse gases (GHGs) emitted or absorbed by lakes are an important component of the global carbon cycle. However, few studies have focused on the GHG dynamics of eutrophic saline lakes, thus preventing a comprehensive understanding of the carbon cycle. Here, we conducted four sampling analyses using a floating chamber in Daihai Lake, a eutrophication saline lake in Inner Mongolia Autonomous Region, China, to explore its carbon dioxide (CO) and methane (CH) emissions.

Anti-reflux effects of a novel esophagogastric asymmetric anastomosis technique after laparoscopic proximal gastrectomy.

Background: Reflux esophagitis is a common postoperative complication of proximal gastrectomy. There is an urgent need for a safer method of performing esophageal-gastric anastomosis that reduces the risk of reflux after proximal gastrectomy. We hypothesize that a novel technique termed esophagogastric asymmetric anastomosis (EGAA) can prevent postoperative reflux in a safe and feasible manner.

Fluxes in CO and CH and influencing factors at the sediment-water interface in a eutrophic saline lake.

Although saline aquatic ecosystems are significant emitters of greenhouse gases (GHGs), dynamic changes in GHGs at the sediment-water interface remain unclear. The present investigation carried out a total of four sampling campaigns in Daihai Lake, which is a eutrophic saline lake situated in a semi-arid area of northern China. The aim of this study was to investigate the spatio-temporal dynamics of carbon dioxide (CO) and methane (CH) fluxes at the sediment-water interface and the influencing factors.

Perylene diimide/iron phthalocyanine Z-scheme heterojunction with strong interfacial charge transfer through π-π interaction: Efficient photocatalytic degradation of tetracycline hydrochloride.

The development of an all-organic Z-scheme heterojunction photocatalyst with the matched band structure, efficient electron transfer and excellent photocatalytic performance is valuable for a sustainable future. A novel perylene diimide/phthalocyanine iron (PDI/FePc) heterojunctions with strong π-π interaction were synthesized by a self-assembled method, which exhibited strong visible-light-driven photocatalytic degradation activities of tetracycline hydrochloride (TC). The TC removal rate over PDI/FePc was achieved three times and 87.

Deletion of DYRK1A Accelerates Osteoarthritis Progression Through Suppression of EGFR-ERK Signaling.

Dual-specificity tyrosine phosphorylation regulated kinase 1A (DYRK1A) signaling is involved in the dynamic balance of catabolism and anabolism in articular chondrocytes. This study aimed to investigate the roles and mechanism of DYRK1A in the pathogenesis of osteoarthritis (OA). The expressions of DYRK1A and its downstream signal epidermal growth factor receptor (EGFR) were detected in the cartilage of adult wild-type mice with destabilized medial meniscus (DMM) and articular cartilage of patients with OA.

One-Pot Synthesis of N-Doped NiO for Enhanced Photocatalytic CO Reduction with Efficient Charge Transfer.

The green and clean sunlight-driven catalytic conversion of CO into high-value-added chemicals can simultaneously solve the greenhouse effect and energy problems. The controllable preparation of semiconductor catalyst materials and the study of refined structures are of great significance for the in-depth understanding of solar-energy-conversion technology. In this study, we prepared nitrogen-doped NiO semiconductors using a one-pot molten-salt method.

A case of liposarcoma with osteolysis of the maxilla as the first symptom and review of the literature.

Liposarcomas are extremely rare in the oral cavity and mainly observed in the buccal mucosa, tongue, floor of the mouth, gingiva, and lips, while those occurring in the jaws have not been reported so far. Clinically, the initial presentation of liposarcoma is usually a painless soft tissue mass. The aim of this study was to report a case of liposarcoma with osteolysis of the maxilla as the first symptom, and review the relevant literature to summarize its clinical features, imaging features, pathological features and treatment methods.

Research on Load Reverse Engineering and Vibration Fatigue Analysis Technology of Rapid Box Wagon.

The overall stiffness and modal frequency of the car body of a rapid box car are reduced by the design of the full-side open movable side door structure. The vibration fatigue performance of the welded structure in this car body needs to be verified. The rigid-flexible coupling model of the rapid box wagon was established first, and the model was verified by modal test data.