Simple automated radiosynthesis of 10-[11C]methoxy-20(S)-camptothecin and biodistribution in normal mice.

10-[(11)C]methoxy-20(S)-camptothecin was synthesized automatically. The radiochemical yield was 30%-50% (all calculated at EOB, n=20) with [(11)C]methyl triflate as a methylating agent. The radiochemical purity was greater than 96%, and the specific activity was 8.

Comparison of MRI, F-18 FDG, and 11C-choline PET/CT for their potentials in differentiating brain tumor recurrence from brain tumor necrosis following radiotherapy.

Objective: To compare potentials of magnetic resonance imaging (MRI), F-18 FDG, and 11C-Choline PET/CT in differentiating brain tumor recurrence from necrosis after radiotherapy.

Methods: Fifty-five patients with suspected brain tumor recurrence or necrosis after radiotherapy underwent MRI, F-18 FDG, and 11C-choline PET/CT examinations, and all the patients were followed up for at least 11 months. Lesion diagnoses based on medical imaging were compared with pathology or follow-up outcomes.

Prognostic value of 2-[18F]fluoro-2-deoxy-D-glucose uptake as measured by PET scan in patients with non-small cell lung cancer.

This study aimed to evaluate the prognostic value of 2-[18F]fluoro-2-deoxy-D-glucose (18F-FDG) uptake determined by positron emission tomography (PET) in patients with non-small cell lung cancer (NSCLC) in relation to disease stage and/or tumor histology. A retrospective review of 144 patients with newly diagnosed lung cancer undergoing PET imaging was performed. Differences in survival were compared by univariate and multivariate analyses.

Role of fluorodeoxyglucose-PET versus fluorodeoxyglucose-PET/computed tomography in detection of unknown primary tumor: a meta-analysis of the literature.

The objectives of this study were to evaluate the diagnostic accuracy of fluorodeoxyglucose (FDG)-PET and FDG-PET/computed tomography (CT) in the detection of primary tumors in patients presenting with carcinoma of unknown primary (CUP) unidentified by conventional workup, and to compare the statistical difference between the FDG-PET and FDG-PET/CT. Twenty-eight studies (involving a total of 910 patients) published between 1990 and 2007 were reviewed. These studies evaluated the role of FDG-PET and FDG-PET/CT in the detection of unknown primary tumors after physical examination and conventional workup failed to detect a primary tumor.

Misdiagnoses of 11C-choline combined with 18F-FDG PET imaging in brain tumours.

Background And Objective: The widely applied F-FDG is known for its disadvantage in brain tumour PET imaging because of its high background uptake. C-choline can achieve high contrast of brain tumour imaging and was expected to have higher sensitivity and specificity. We analysed the misdiagnoses in C-choline PET imaging in brain tumours with the aim of improving the accuracy of diagnosis with C-choline PET imaging.

The prevalence of dementia in the People's Republic of China: a systematic analysis of 1980-2004 studies.

Background: Dementia has been a major public health problem. However, there has not yet been a nationwide investigation or systematic analysis of the prevalence of dementia in China from 1980 to 2004.

Objectives: The aim of this study was to analyse the prevalence of dementia and its major subtypes [Alzheimer disease (AD), vascular dementia (VD)] among the population aged 60 years and older in China from 1980 to 2004.

[Growth characteristics of A549 lung adenocarcinoma multicellular spheroid].

Background: Owing to the limitation of monolayer tumour cells or transplanted tumor in radiation biology, multicellular spheroid (MTS) as a model of entity tumor had a wide range of application. This research aims to study the growth characteristics of A549 lung adenocarcinoma MTS so as to choose the best ones to perform experiments.

Methods: 1.

L-[1-13C] phenylalanine breath test results reflect the activity of phenylalanine hydroxylase in carbon tetrachloride acute injured rat liver.

L-[1-13C] phenylalanine breath tests (PheBTs) have been used to determine the hepatocyte functional capacity of patients. This study investigated the relationship between the PheBT parameter 13C excretion rate constant (PheBT-k) and activity of the phenylalanine metabolic rate-limiting enzyme phenylalanine hydroxylase (PAH) in rat liver. We noted that the time-course curves of 13C excretion presented as a single peak, which appeared 2 min after administration of L-[1-13C] phenylalanine (13C-Phe).

[Application of 18F-FDG PET/CT scan in following-up of nasopharyngeal carcinoma after radiotherapy].

Background & Objective: Local relapse,tumor residue, and whole body metastases of nasopharyngeal carcinoma (NPC) after radiotherapy were mainly confirmed by CT, MRI, SPE/CT, and PET examinations. This study was to discuss the value of F-18-fluoro-2-deoxy-d-glucose positron emission tomography/computed tomography (PET/CT) in detecting suspected recurrence or tumor residue, and whole body metastases of NPC after radiotherapy.

Methods: PET/CT were performed on 38 NPC patients 3-36 months after radiotherapy.