Overexpression of ETV2 in BMSCs promoted wound healing in cutaneous wound mice by triggering the differentiation of BMSCs into endothelial cells and modulating the transformation of M1 phenotype macrophages to M2 phenotype macrophages.

This study aimed to investigate the effects of E26-transformation-specific variant-2 (ETV2) overexpression on wound healing in a cutaneous wound (CW) model and clarify associated mechanisms. pLVX-ETV2 lentivirus expressing ETV2 was constructed and infected into BMSCs to generate ETV2-overexpressed BMSCs (BMSCs+pLVX+ETV2). The RT-PCR assay was applied to amplify ETV2, VE-cadherin, vWF, ARG-1, IL-6, iNOS, TGF-β, IL-10, TNF-α.

On-orbit space optical communication demonstration with a 22 s acquisition time.

The inherent small divergence angle of space optical communication poses significant challenges to establishing communication links. Therefore, laser link acquisition becomes a crucial technology in optical communication, with a primary focus on reducing the acquisition time effectively. Conventional optical communication acquisition techniques fail to address the error effects caused by satellite insertion into the Earth orbit, thus unable to meet the rapid establishment demands of laser links in satellite optical communication networks.

On-orbit demonstration of inter-satellite free-space optical stable communication enabled by integrated optical amplification of HPA and LNA.

Satellite free-space optical (FSO) communication is very promising in improving the bandwidth and capacity of space information networks in the future. However, the inter-satellite transmission distance of over 1000 km leads to unstable optical beam pointing, acquisition, and tracking and then generates optical power jitter by a large margin before detection-demodulation. Therefore, it is difficult to realize high-stability and long-time FSO communication between satellites due to the generated bit error rate (BER) by jitter.

Beam Scanning and Capture of Micro Laser Communication Terminal Based on MEMS Micromirrors.

With the development of space laser communication and the planned deployment of satellite Internet constellations, there is a growing demand for microminiature laser communication terminals. To meet the requirements of size, weight and power (SWaP), miniaturized terminals require smaller drive components to complete on-orbit scanning and capture, which must be fast and efficient to enable satellite laser communication networks. These miniaturized laser communication terminals are highly susceptible to the impact of the initial pointing accuracy of the laser beam and microvibrations of the satellite platform.

Predictive value of bone morphogenetic protein-7, thromboxane A2, and osteoprotegerin for prognosis of patients with distal radius fractures.

Objectives: This study aims to investigate the predictive value of bone morphogenetic protein-7 (BMP-7), thromboxane A2 (TXA2), and osteoprotegerin (OPG) for the prognosis of patients with distal radius fractures.

Patients And Methods: Between January 2021 and January 2022, a total of 124 patients (71 males, 53 females; mean age: 49.8±5.

SOX9 Inhibits the Progression of Osteonecrosis of the Femoral Head via the Activation of the Wnt/Beta-Catenin Pathway.

In this study, we aimed to explore whether the SRY-box transcription factor 9 (SOX9) can play protective roles against the occurrence and development of osteonecrosis of the femoral head (ONFH) by regulating the proliferation, apoptosis, and osteogenic differentiation of human bone marrow stromal cells (hBMSCs) via the Wnt/β-catenin pathway. We used 1600 mg of glucocorticoid (GC) to induce hBMSCs to establish an ONFH cell model and performed various experiments. Reverse transcription-quantitative polymerase chain reaction and western blotting assays were used to determine the expression levels of SOX9 and osteoblast markers, such as the RUNX family transcription factor 2 (RUNX2), alkaline phosphatase (ALP), osterix, Wnt3a, and β-catenin.

A novel modified Winograd surgical tricks and tips with a "bird flap" for the treatment of ingrown toenails.

Background: The Winograd technique is the most commonly used surgical treatment for ingrown toenails. We describe a novel modified approach, more effective and simpler to perform with a better cosmetic outcome.

Methods: We retrospectively included 45 and 39 patients with 67 and 58 ingrown toenails who underwent our modified Winograd technique and the Winograd technique, respectively, from July 2017 to June 2020, and obtained data after 3, 6, and 12 months of follow-up.

Artificial Neural Network Model for the Prediction of Thermal Conductivity of Saturated Liquid Refrigerants and -Alkanes.

In this paper, a feed-forward back-propagation artificial neural network (ANN) is proposed to correlate and predict the thermal conductivity from the triple point temperature up to 0.98 times critical temperature ( ) for 23 refrigerants and 11 -alkanes. It requires the temperature () as well as the molecular mass (), acentric factor (ω), critical temperature, and critical pressure ( ) as input variables.

Exhausting circ_0136474 and Restoring miR-766-3p Attenuate Chondrocyte Oxidative Injury in IL-1β-Induced Osteoarthritis Progression Through Regulating DNMT3A.

Circular RNA circ_0136474 is a new contributor of human osteoarthritis (OA) by suppressing chondrocyte proliferation. However, its role and mechanism in OA chondrocyte injury remain ill defined. Herein, we performed real-time quantitative PCR to detect RNA expression of circ_0136474, microRNA (miR)-766-3p, and DNA methyltransferase 3A (DNMT3A) and utilized Western blotting to measure protein expression of DNMT3A, matrix metalloproteinase-1 (MMP1), MMP13, collagen II, proliferating cell nuclear antigen (PCNA) and B cell lymphoma (Bcl)-2, and Bcl-2-associated X protein (Bax).

An experimental investigation of the dynamic fracture behavior of 3D printed nacre-like composites.

The dynamic fracture behavior of 3D printed nacre-like composites was fully characterized by performing three-point bending dynamic fracture experiments. Nacre-like specimens with brick and mortar microstructures were fabricated with dual-material 3D printing technology. A brittle rigid material and a rubber-like material were selected for the brick layers and adhesive of the composite, respectively.