Publications by authors named "Xiangsen Guo"

Employing longer wavelengths in optical microscopic imaging is recognized for its advantage in deep penetration. However, the 1550 nm spectrum band is often overlooked due to water's high absorption coefficient. This study investigates the feasibility of 1550 nm center wavelength-based optical coherence tomography (OCT) for imaging the cerebral vasculature and blood flow in the mouse brain cortex.

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The accurate measurement of blood flow velocity in the capillary network is challenging due to the small size of the vessels and the slow flow of red blood cells (RBCs) within the vessel. Here, we introduce an autocorrelation analysis-based optical coherence tomography (OCT) method that takes less acquisition time to measure the axial blood flow velocity in the capillary network. The axial blood flow velocity was obtained from the phase change in the decorrelation period of the first-order field autocorrelation function (g) of the OCT field data, which was acquired with M-mode acquisition (repeated A-scans).

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