Metapath-aggregated heterogeneous graph neural network for drug-target interaction prediction.

Drug-target interaction (DTI) prediction is an essential step in drug repositioning. A few graph neural network (GNN)-based methods have been proposed for DTI prediction using heterogeneous biological data. However, existing GNN-based methods only aggregate information from directly connected nodes restricted in a drug-related or a target-related network and are incapable of capturing high-order dependencies in the biological heterogeneous graph.

Learning Disentangled Representation for Multimodal Cross-Domain Sentiment Analysis.

Multimodal cross-domain sentiment analysis aims at transferring domain-invariant sentiment information across datasets to address the insufficiency of labeled data. Existing adaptation methods achieve well performance by remitting the discrepancies in characteristics of multiple modalities. However, the expressive styles of different datasets also contain domain-specific information, which hinders the adaptation performance.

Accurate diagnosis of pulmonary nodules using a noninvasive DNA methylation test.

BACKGROUNDCurrent clinical management of patients with pulmonary nodules involves either repeated low-dose CT (LDCT)/CT scans or invasive procedures, yet causes significant patient misclassification. An accurate noninvasive test is needed to identify malignant nodules and reduce unnecessary invasive tests.METHODWe developed a diagnostic model based on targeted DNA methylation sequencing of 389 pulmonary nodule patients' plasma samples and then validation in 140 plasma samples independently.