Vegfr3 activation of Pkd2l1 CSF-cNs triggers the neural stem cell response in spinal cord injury.

Activating adult neural stem cells (NSCs) located within the spinal cord niche is considered a promising therapeutic approach for treating spinal cord injury (SCI). Cerebrospinal fluid (CSF)-contacting neurons expressing Pkd2l1 exhibit phenotypic and molecular traits similar to those of adult NSCs. However, the mechanism responsible for regulating the activation of Pkd2l1 CSF-cNs still needs to be discovered.