Berberine Improves Chemo-Sensitivity to Cisplatin by Enhancing Cell Apoptosis and Repressing PI3K/AKT/mTOR Signaling Pathway in Gastric Cancer.

Gastric cancer is one of the most common malignancies ranks as the second leading cause of cancer-related mortality in the world. Cisplatin (DDP) is commonly used for gastric cancer treatment, whereas recurrence and metastasis are common because of intrinsic and acquired DDP-resistance. The aim of this study is to examine the effects of berberine on the DDP-resistance in gastric cancer and explore the underling mechanisms.

[Effect of ambient air PM10 concentration on the hospital outpatient visit of respiratory diseases in Shenzhen City].

Objective: To explore quantitatively the impact of the ambient air PM10 concentration (inhalable particulate matter) on the hospital outpatients for respiratory diseases.

Methods: Daily hospital visits data in 2008 was collected from a hospital in Shenzhen, meteorological data and air pollution data were collected from Shenzhen Meteorological Bureau and Shenzhen Environmental Protection Bureau, respectively. There was a time serial analysis using semi-parameter generalized additive model extend Poisson regression, after controlled with long-term tend, the-day-of-week, meteorological factors and other air pollutants.