Publications by authors named "Xiangqing Hei"
Purpose: To compare the efficacy of intravitreal antivascular endothelial growth factor (anti-VEGF) agents with oral carbonic anhydrase inhibitors (CAIs) in treating cystoid macular edema (CME) secondary to retinitis pigmentosa (RP).
Methods: This retrospective study analyzed 98 patients (98 eyes) with RP-CME: 47 (48.0%) received intravitreal anti-VEGF agents (Ranibizumab or Bevacizumab) and 51 (52.
SOX9 Induces Orbital Fibroblast Activation in Thyroid Eye Disease Via MAPK/ERK1/2 Pathway.
Invest Ophthalmol Vis Sci
February 2024
Article Synopsis
- The study investigates the expression and role of SOX9 in orbital fibroblasts from patients with thyroid eye disease (TED) compared to healthy controls.
- Results reveal that SOX9 is significantly elevated in TED orbital fibroblasts and influences key cellular activities such as contraction, migration, and proliferation via the MAPK/ERK1/2 signaling pathway.
- The findings suggest that targeting SOX9 and its downstream effect on the epidermal growth factor receptor (EGFR) could provide new therapeutic strategies for treating orbital fibrosis in TED.
Retinal ischemia-reperfusion (RIR) injury caused by high intraocular pressure (IOP) is an important risk factor contributing to retinal ganglion cell (RGC) death, eventually causing blindness. A key progressive pathological process in the development of RIR is the death of RGCs. However, the detailed mechanisms underlying RGC death caused by RIR have not yet been clearly elucidated, and effective treatments are lacking.
View Article and Find Full Text PDFLutein (LU) is a carotenoid that has recently been implicated in multiple roles in fibrosis, inflammation, and oxidative stress. Thyroid-associated ophthalmopathy (TAO) is particularly relevant to these pathological changes. We thus aim to probe the potential therapeutic effects of TAO in an in vitro model.
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- Previous research on ptosis recurrence after surgical correction has largely overlooked the role of refractive errors, prompting this study to explore their potential link in pediatric patients with congenital ptosis.
- The study analyzed data from 85 patients who underwent frontalis muscle flap suspension for simple congenital ptosis, focusing on postoperative eyelid height and refractive changes over time.
- The findings indicated that factors like postoperative cylindrical diopter and laterality were linked to recurrence, while preoperative and postoperative spherical metrics showed no significant correlation, suggesting improvements in refractive correction may help reduce recurrence rates in ptosis cases.
Background: Corneal neovascularization (CNV) caused by alkali burn injury is tightly associated with an inflammatory reaction and can lead to vision loss. Melatonin is involved in anti-inflammation and anti-angiogenesis, but its role in CNV has not yet been investigated.
Methods: We induced CNV using sodium hydroxide (NaOH) and compared the reactions of vehicle control and melatonin-treated male C57BL/6 mice at 7 and 14 days following the corneal burn.
Orbital fibrosis is a hallmark of tissue remodeling in thyroid-associated ophthalmopathy (TAO). Previous studies have shown that interleukin (IL)-11 plays a pivotal profibrotic role in various inflammatory and autoimmune diseases. However, the expression pattern of IL-11 in patients with TAO and whether IL-11 is mechanistically linked with pathological fibrosis remains unknown.
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