Publications by authors named "Xiangping Hou"
Article Synopsis
- The study investigates the prevalence of carbapenem-resistant Enterobacterales (CREs) in Xinjiang, China, focusing on the genomic characteristics of carbapenem-resistant Klebsiella pneumoniae (CRKP) ST11-KL30.
- 85 CRE isolates were collected from 2021 to 2023, with CRKP being the most common, especially the KPC carbapenemase type, and three CRKP clones were identified, including the new recombinant ST11-KL30 with distinct virulence features.
- The results highlight a concerning rise of ST11-KL30 in southern Xinjiang, stressing the need for ongoing surveillance due to its potential spread and unique biofilm formation capabilities.
miR-129-5p alleviates LPS-induced acute kidney injury via targeting HMGB1/TLRs/NF-kappaB pathway.
Int Immunopharmacol
December 2020
Introduction: The present study aimed to investigate whether miR-129-5p can regulate high-mobility group box protein 1 (HMGB1)-modulated TLRs/NF-kappaB inflammatory pathway that contributed to lipopolysaccharide (LPS)-induced podocyte apoptosis and acutekidneyinjury (AKI).
Material And Methods: In vitro and in vivo models of sepsis were simulated using LPS-administrated podocytes and mice, respectively. The effects of LPS, mR-129-5p mimics and short hairpin RNA of HMGB1 (sh-HMGB1) on podocyte apoptosis were monitored using TUNEL staining.
Septic cardiomyopathy, which is one of the features of multi-organ dysfunction in sepsis, is characterized by ventricular dilatation, reduced ventricular contractility, and reduction in ejection fraction and, if severe, can lead to death. To date, there is no specific therapy that exists, and its treatment represents a large unmet clinical need. Herein, we investigated the effects and underlying anti-inflammatory mechanisms of hydrogen gas in the setting of lipopolysaccharide (LPS)-induced cardiomyocytes injury.
View Article and Find Full Text PDFObjective: To observe the effect of Cornus Officinalis total glycosides (COTG) and Cornus polysaccharides (CP) on myocardial mitochondria and expression levels of glycogen synthase kinase-3β (GSK-3β) of acute myocardial infarction (AMI) rats.
Methods: The AMI rat model was established by ligating the left anterior descending branch of coronary artery. Rats were divided into 5 groups according to random digit table, i.