Multimodal separation and cross fusion network based on Raman spectroscopy and FTIR spectroscopy for diagnosis of thyroid malignant tumor metastasis.

The diagnosis of cervical lymph node metastasis from thyroid cancer is an essential stage in the progression of thyroid cancer. The metastasis of cervical lymph nodes directly affects the prognosis and survival rate of patients. Therefore, timely and early diagnosis is crucial for effective treatment and can significantly improve patients' survival rate and quality of life.

Toxicokinetics and responses of multiple biomarkers of sediment-associated fluoroquinolones in an ecologically important freshwater snail Bellamya aeruginosa.

Fluoroquinolones (FQs) have the propensity to accumulate in sediments once introduction into aquatic environments, thereby posing potential threats to benthic organisms, yet the ecotoxicity of sediment-associated FQs remains unclear. In this study, the toxicokinetics and responses of multiple biomarkers in Bellamya aeruginosa, exposed to the three commonly used FQs (norfloxacin, NOR; ciprofloxacin, CIP; levofloxacin, LEVO) at environmentally relevant concentrations were investigated under sediment exposure scenario. The results revealed that FQs were effectively ingested by B.

A multi-center study to predict the risk of intraoperative hypothermia in gynecological surgery patients using preoperative variables.

Objectives: Hypothermia is highly common in patients undergoing gynecological surgeries under general anesthesia, so the length of hospitalization and even the risk of mortality are substantially increased. Our aim was to develop a simple and practical model to preoperatively identify gynecological surgery patients at risk of intraoperative hypothermia.

Methods: In this retrospective study, we collected data from 802 patients who underwent gynecological surgery at three medical centers from June 2022 to August 2023.

Clinical use of tigecycline may contribute to the widespread dissemination of carbapenem-resistant hypervirulent strains.

The emergence of carbapenem-resistant hypervirulent (CR-hvKP) poses grave threats to human health. These strains increased dramatically in clinical settings in China in the past few years but not in other parts of the world. Four isogenic strains, including classical , carbapenem-resistant (CRKP), hypervirulent (hvKP) and CR-hvKP, were created and subjected to phenotypic characterization, competition assays, mouse sepsis model and rat colonization tests to investigate the mechanisms underlying the widespread nature of CR-hvKP in China.

The prevalence of HPV among 164,137 women in China exhibited some unique epidemiological characteristics.

Objective: The persistence of HPV infection is a significant etiological factor in the development of cervical cancer. The present study investigated the prevalence and genotype distribution of human papillomavirus (HPV) in a cohort of 164,137 unvaccinated women from Wenzhou, aiming to provide guidance for clinics in the cervical cancer screening and HPV vaccination strategies.

Methods: The present retrospective study included a total of 164,137 women, comprising 118,484 outpatients and 45,653 healthy female subjects recruited from 2015 to 2020.

Amiloride alleviates morphine tolerance by suppressing ASIC3-dependent neuroinflammation in the spinal cord.

Background: The use of morphine in clinical medicine is severely constrained by tolerance. Therefore, it is essential to examine pharmacological therapies that suppress the development of morphine tolerance. Amiloride suppressed the expression of inflammatory cytokines by inhibiting microglial activation.

Interactive Allocation of Water Pollutant Initial Emission Rights in a Basin under Total Amount Control: A Leader-Follower Hierarchical Decision Model.

The initial emission rights allocation is the key measure to achieve the goal of total amount control and deepen the emission trading system. Although many studies have focused on the modeling of initial emission rights allocation, such as using game theory and multi-objective optimization methods, few studies have observed the hierarchical relationship of mutual interference and restriction between watershed management agency and local governments in each subarea during allocation. This relationship directly affects the rationality of the results of regional emission rights allocation.

Recent Advances for Electrode Modifications in Flow Batteries: Properties, Mechanisms, and Outlooks.

Flow batteries (FBs) have been demonstrated in several large-scale energy storage projects, and are considered to be the preferred technique for large-scale long-term energy storage in terms of their high safety, environmental friendliness, and long life, including all-vanadium flow batteries (VFBs) and Fe-Cr flow batteries (ICFBs). As the electrochemical reaction site, the electrode parameters, such as the specific surface area, active site, and so on, have a significant impact on the flow battery performance and reliability. Extensive research has been carried out on electrode modification to improve the current density and energy efficiency of the FBs.

Invisible Effect of Virtual Water Transfer on Water Quantity Conflict in Transboundary Rivers-Taking Ili River as a Case.

Water stress in countries within a drainage basin exacerbates the water quantity conflict in transboundary rivers. However, few studies considered the invisible effect of virtual water transfer on water quantity conflict by intensifying water stress. Therefore, this study, with Ili River as the case, collects data on Virtual Water Trade (VWT) from 1990 to 2015, uses water stress index (WSI) to assess water stress values under two scenarios (with or without virtual water transfer), and takes Grey Verhulst Model to predict two scenarios water stress values respectively.

Design of Flexible Film-Forming Polydopamine/Polypyrrole/Nanodiamond Hierarchical Structure for Broadband Microwave Absorption.

Microwave-absorbing materials are widely used in numerous fields, including the military, daily protection, etc. Currently, in addition to being lightweight and highly efficient, good film-forming processing characteristics and environmental stability are also required for the practical application of microwave-absorbing materials, which, in general, are difficult to make compatible. In this paper, a mulberry-like PDA/PPy/ND hierarchical structure was prepared by in situ polymerization.

Systematic review and meta-analysis of the prognostic value of Narcotrend monitoring of different depths of anesthesia and different Bispectral Index (BIS) values for cognitive dysfunction after tumor surgery in elderly patients.

Background: To study the effect of Narcotrend monitoring on the incidence of early postoperative cognitive dysfunction (POCD) under different Bispectral Index (BIS) conditions and the effect of different depths of anesthesia on the incidence of POCD.

Methods: We performed a literature search of the PubMed, Embase, OVID (database system made by Ovid Technologies, USA), Chinese Biomedical Literature Database (CBM), China National Knowledge Infrastructure (CNKI), VIP Chinese Sci-tech Journals Database, Wanfang Data, etc. from the date of establishment of the database until December 31, 2020.

Two naturally occurring mutations of human GPR103 define distinct G protein selection bias.

The neuropeptide 26RFa plays important roles in the regulation of many physiological functions. 26RFa has been recognized as an endogenous ligand for receptor GPR103. In the present study, we demonstrate that GPR103 dually couples to Gαq and Gαi/o proteins.

Ecological Compensation Standard of Trans-Boundary River Basin Based on Ecological Spillover Value: A Case Study for the Lancang-Mekong River Basin.

Ecological compensation is an effective means to solve the conflict of interests among trans-boundary river basin countries. How to determine the ecological compensation standard is the core of ecological compensation. On the basis of the emergy synthesis method, we developed an emergy-water resources ecological footprint model for trans-boundary river basin countries.

Analysis of Tradable Water Volumes of Industry in Water-Rich Areas of China: A Case Study of Changsha City.

Tradable water volumes is one of the basic elements of water-rights trading. In China, water-rights transactions mostly occur in water-deficient areas. However, the water-rich areas are also facing serious water-shortage problems.

Fair and Reasonable Allocation of Trans-Boundary Water Resources Based on an Asymmetric Nash Negotiation Model from the Satisfaction Perspective: A Case Study for the Lancang-Mekong River Bain.

The issue of trans-boundary water conflict has become an important factor affecting the relations between basin countries. The key to solve the current conflict problem is to realize the fair and reasonable allocation of trans-boundary water resources. Based on the satisfaction perspective, we developed an asymmetric Nash negotiation model to obtain an optimal and feasible allocation scheme for the trans-boundary water resources.

Carbonized polyaniline bridging nanodiamond-graphene hybrids for enhanced microwave absorptions with ultrathin thickness.

For conventional design of the electromagnetic absorption materials, introduction of magnetic materials into dielectric materials has been found to achieve better impedance matching, but lead to increase in weight and decrease in chemical stability, therefore limiting their practical applications. In this work, metal-free electromagnetic coupling was achieved by the design of nitrogen-doped nanodiamond/graphene hybrids. Polyaniline is used to self-assembled bridge the nanodiamond and graphene, and the carbonization is carried out for construction and regulation of the C•••N polarization and nitrogen doping.

Sevoflurane induces apoptosis of isolated placental trophoblast cells and stimulates expressions of TNF-α and IL-6.

Studies have shown that narcotic drugs may affect the function of placental trophoblast cells. The aim of this study was to investigate the effect of sevoflurane on apoptosis and proinflammatory cytokines in isolated placental trophoblast cells. The primary placental trophoblast cells were obtained from a total of 20 parturients, which were randomly divided into 4 groups and treated with 3% sevoflurane for 0 minutes (S0), 15 minutes (S15), 30 minutes (S30) and 60 minutes (S60).

[Efficacy of Ropivacaine injection at acupoints for labor analgesia and its effect on breastfeeding and serum prolactin].

Objective: To investigate the efficacy of acupoint injection of Ropivacaine for labor analgesia and its effect on breastfeeding and prolactin secretion.

Methods: A total of 80 primipara who asked to receive labor analgesia were randomized into epidural analgesia group (＝35) and acupoint injection group (＝36), and other 36 primipara who refused to receive labor analgesia were subjected to the control group. The labor analgesia began to be performed when the puerpera's uterine orifice opened about ≥3 cm (the first stage of labor), including puerpera controlled epidural analgesia (PCEA, Sufentainil ＋ 0.

Anatomy of the Cun Position at Wrist and Its Application in Pulse Diagnosis.

Information on anatomy of the Cun position at wrist is lacking; whether the blood vessel taking pulse in Cun is the radial artery or the superficial palmar branch is also clinically controversial. The objective was to investigate the boundaries and contents, and the vascular distribution and their pulse points in Cun. Thirty-two upper extremities of 16 human cadavers were investigated for dissection and observation.

Peptide P7 inhibits the bFGF-stimulated proliferation and invasion of SKOV3 cells.

Peptide P7 specifically binds with basic fibroblast growth factor (bFGF) to inhibit the proliferation and invasion of numerous types of cancer cell. However, this effect has remained to be demonstrated in ovarian cancer-derived cell lines. In the present study, the protein P7 was used treat bFGF-stimulated SKOV3 epithelial ovarian cancer cells to explore the therapeutic potential of P7.

Correction to: Genome-Wide Array Analysis Reveals Novel Genomic Regions and Candidate Gene for Intellectual Disability.

An Online First version of this article was made available online.

Genome-Wide Array Analysis Reveals Novel Genomic Regions and Candidate Gene for Intellectual Disability.

Introduction: Intellectual disability (ID) is often sporadic, and its complex etiology makes clinical diagnosis extremely difficult.

Objective: The aims of this study were to detect copy number variations (CNVs) in patients with ID and to analyze the correlation between pathogenic CNVs and clinical phenotype.

Methods: After cases of ID caused by metabolic dysfunction or environmental factors were excluded, 64 patients with moderate to severe ID were enrolled.

[Efficacy of ropivacaine injection at acupoints for labor analgesia and its effect on cortisol level in parturients].

Objective: To evaluate the efficacy of ropivacaine injection at the acupoints Hegu and Sanyinjiao for labor analgesia and its effects on cortisol level in parturients.

Methods: A total of 120 ASA class I-II nulliparous women undergoing spontaneous term labor (37 to 41 weeks of gestation) with a live, singleton fetus in the occiput anterior position and requiring labor analgesia with acupuncture were enrolled in this study. These women were randomized into study group and control group and received injections of 1 mL of 0.