Identification of a novel prognostic signature for breast cancer derived from post-translational ubiquitin and ubiquitin-like modification-related genes.

Ubiquitin and ubiquitin-like (UUL) modifications play pleiotropic functions and are subject to fine regulatory mechanisms frequently altered in cancer. However, the comprehensive impact of UUL modification on breast cancer remains unclear. Transcriptomic and clinical data of breast cancer were downloaded from TCGA and GEO databases.

Association of neutrophil to lymphocyte ratio, platelet to lymphocyte ratio, mean platelet volume with the risk of gestational diabetes mellitus.

Objective: In the present study, we aimed to investigate the correlation of neutrophil to lymphocyte ratio, platelet to lymphocyte ratio, mean platelet volume with the risk of gestational diabetes mellitus.

Methods: The study enrolled 120 pregnant women who were the 24th and 28th weeks of gestation, including GDM group ( = 58), the control group ( = 62). The NLR, PLR and MPV levels were measured.

Preferential recruitment of Th17 cells to cervical cancer via CCR6-CCL20 pathway.

Our previous studies suggest that Th17 cells accumulate within tumor tissues and correlate with recurrence of cervical cancer patients. However, the source of the increased tumor-infiltrating Th17 cells remains poorly understood. We investigated the prevalence, phenotype and trafficking property of Th17 cells in patients with cervical cancer.

Prediction of local recurrence in cervical cancer by a Cox model comprised of lymph node status, lymph-vascular space invasion, and intratumoral Th17 cell-infiltration.

The identification of cervical cancer patients at high risk of local recurrence is urgent to improve the selection of patients for more aggressive treatment. The immune contexture in human tumors has vital impact on clinical outcome. Our aim in the study was to establish a predictive model of local recurrence by assessing the prognostic significance of clinicopathologic features and five immune markers within the tumor microenvironment in cervical cancer.